NDLI: Prostate Cancer Grading: Use of Graph Cut and Spatial Arrangement of Nuclei

Content Provider	IEEE Xplore Digital Library
Author	Nguyen, K. Sarkar, A. Jain, A.K.
Copyright Year	1982
Abstract	Tissue image grading is one of the most important steps in prostate cancer diagnosis, where the pathologist relies on the gland structure to assign a Gleason grade to the tissue image. In this grading scheme, the discrimination between grade 3 and grade 4 is the most difficult, and receives the most attention from researchers. In this study, we propose a novel method (called nuclei-based method) that 1) utilizes graph theory techniques to segment glands and 2) computes a gland-score (based on the spatial arrangement of nuclei) to estimate how similar a segmented region is to a gland. Next, we create a fusion method by combining this nuclei-based method with the lumen-based method presented in our previous work to improve the performance of grade 3 versus grade 4 classification problem (the accuracy is now improved to 87.3% compared to 81.1% of the lumen-based method alone). To segment glands, we build a graph of nuclei and lumina in the image, and use the normalized cut method to partition the graph into different components, each corresponding to a gland. Unlike most state-of-the-art lumen-based gland segmentation method, the nuclei-based method is able to segment glands without lumen or glands with multiple lumina. Moreover, another important contribution in this research is the development of a set of measures to exploit the difference in nuclei spatial arrangement between grade 3 images (where nuclei form closed chain structure on the gland boundary) and grade 4 image (where nuclei distribute more randomly in the gland). These measures are combined to generate a single gland-score value, which estimates how similar a segmented region (which is a set of nuclei and lumina) is to a gland.
Sponsorship	IEEE Engineering in Medicine and Biology Society IEEE Nuclear and Plasma Sciences Society IEEE Signal Processing Society IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society
Starting Page	2254
Ending Page	2270
Page Count	17
File Size	4894999
File Format	PDF
ISSN	02780062
Volume Number	33
Issue Number	12
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Glands Image segmentation Feature extraction Accuracy Cancer Databases Shape stroma Gland segmentation Gleason grading lumen normalized cut nuclei prostate cancer
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering Computer Science Applications Radiological and Ultrasound Technology Software

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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