NDLI: A Robust ISFET pH-Measuring Front-End for Chemical Reaction Monitoring

Content Provider	IEEE Xplore Digital Library
Author	Yuanqi Hu Georgiou, P.
Copyright Year	2007
Abstract	This paper presents a robust, low-power and compact ion-sensitive field-effect transistor (ISFET) sensing front-end for pH reaction monitoring using unmodified CMOS. Robustness is achieved by overcoming problems of DC offset due to trapped charge and transcoductance reduction due to capacitive division, which commonly exist with implementation of ISFETs in CMOS. Through direct feedback to the floating gate and a low-leakage switching scheme, all the unwanted factors are eliminated while the output is capable of tracking a pH reaction which occurs at the sensing surface. This is confirmed through measured results of multiple devices of different sensing areas, achieving a mean amplification of 1.28 over all fabricated devices and pH sensitivity of 42.1 mV/pH. The front-end is also capable of compensating for accumulated drift using the designed switching scheme by resetting the floating gate voltage. The circuit has been implemented in a commercially-available 0.35 μm CMOS technology achieving a combined chemical and electrical output RMS noise of 3.1 mV at a power consumption of 848.1 nW which is capable of detecting pH changes as small as 0.06 pH.
Sponsorship	IEEE Circuits and Systems Society IEEE Engineering in Medicine and Biology Society
Page Count	9
File Size	1528514
Starting Page	177
Ending Page	185
File Format	PDF
ISSN	19324545
Volume Number	8
Issue Number	2
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Capacitors Passivation Logic gates Capacitance CMOS integrated circuits Noise Chemicals sensor array Chemical sensor DNA ion-sensitive field-effect transistor (ISFET) pH sensor reaction monitoring
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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