NDLI: A Motion Adaptive Animal Chamber for PET Imaging of Freely Moving Animals

Content Provider	IEEE Xplore Digital Library
Author	Zhou, V. Eisenhuth, J. Kyme, A. Akhtar, M. Fulton, R. Meikle, S.
Copyright Year	1963
Abstract	Small animal positron emission tomography (PET) is a powerful method for studying the molecular origins of debilitating brain disorders such as dementia, depression and schizophrenia. However, its full potential in such investigations has not yet been realized due to the use of anesthesia to avoid motion artifacts. In spite of preventing motion, anesthestics have the propensity to alter brain function compared to the unanesthetized state. Use of anesthesia also precludes studying an animal's behavior concurrently with imaging. Methods enabling PET imaging without the need for anesthesia would, therefore, serve to improve the quality of, and increase the scope of, PET investigations. Previously, we have reported a motion correction approach for PET imaging of unanesthetized animals confined to a tube. We are currently developing an extension of this technique that allows PET imaging of freely moving rats. Here we report a robot-controlled motion adaptive animal chamber to maintain the head of a freely moving rat within the PET field of view (FOV) during imaging. The chamber is adjusted in the horizontal plane in response to changes in head position reported by a motion tracking system. In live animal experiments within a simulated microPET environment, the motion adaptive chamber led to an increase in the time the head was inside the FOV for all rat behavior types studied. The best improvement (resulting in almost 100% confinement to the FOV) was seen for low activity behaviors. Higher activity behaviors were harder to compensate for completely due to the faster head motion. Overall, for the individual studied the robotic compensation increased the time spent in the FOV from 10% to 88% during approximately 5 hours of trials. We conclude that a robot-controlled motion adaptive chamber is a feasible approach for keeping the animal inside the FOV and an important step towards imaging the brain function of freely moving animals with PET.
Sponsorship	IEEE Nuclear and Plasma Sciences Society Computer Applications in Nuclear and Plasma Sciences (CANPS) Lawrence Berkeley Lab. Lawrence Livermore Nat. Lab. APS College of William and Mary Continuous Electron Beam Accelerator Facility NASA Defence Nuclear Agency Sandia National Laboratories Jet Propulsion Laboratory Brookhaven Nat. Lab. Lawrence Livermore Nat. Lab IEEE/NPPS Radiat. Effects Committee Defence Nuclear Agency/DoD Sandia National Laboratories/DOE Jet Propulsion Laboratory/NASA Phillips Lab./DoD
Starting Page	3423
Ending Page	3431
Page Count	9
File Size	1391667
File Format	PDF
ISSN	00189499
Volume Number	60
Issue Number	5
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Animals Robot kinematics Head Tracking Positron emission tomography positron emission tomography Molecular imaging nuclear imaging PET data quantification and correction methods
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Electrical and Electronic Engineering Nuclear Energy and Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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