NDLI: An Efficient Method for Modeling Kinetic Behavior of Channel Proteins in Cardiomyocytes

Content Provider	IEEE Xplore Digital Library
Author	Chong Wang Beyerlein, P. Pospisil, H. Krause, A. Nugent, C. Dubitzky, W.
Copyright Year	2004
Abstract	Characterization of the kinetic and conformational properties of channel proteins is a crucial element in the integrative study of congenital cardiac diseases. The proteins of the ion channels of cardiomyocytes represent an important family of biological components determining the physiology of the heart. Some computational studies aiming to understand the mechanisms of the ion channels of cardiomyocytes have concentrated on Markovian stochastic approaches. Mathematically, these approaches employ Chapman-Kolmogorov equations coupled with partial differential equations. As the scale and complexity of such subcellular and cellular models increases, the balance between efficiency and accuracy of algorithms becomes critical. We have developed a novel two-stage splitting algorithm to address efficiency and accuracy issues arising in such modeling and simulation scenarios. Numerical experiments were performed based on the incorporation of our newly developed conformational kinetic model for the rapid delayed rectifier potassium channel into the dynamic models of human ventricular myocytes. Our results show that the new algorithm significantly outperforms commonly adopted adaptive Runge-Kutta methods. Furthermore, our parallel simulations with coupled algorithms for multicellular cardiac tissue demonstrate a high linearity in the speedup of large-scale cardiac simulations.
Sponsorship	IEEE Computer Society
Page Count	12
File Size	4878911
Starting Page	40
Ending Page	51
File Format	PDF
ISSN	15455963
Volume Number	9
Issue Number	1
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Kinetic theory Mathematical model Equations Biomembranes Numerical models Heuristic algorithms Markov model. Cardiomyocyte arrhythmia channel protein conformation kinetic pathway differential equations
Content Type	Text
Resource Type	Article
Subject	Applied Mathematics Genetics Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

An Efficient Method for Modeling Kinetic Behavior of Channel Proteins in Cardiomyocytes

A Second-Order Algorithm for Solving Dynamic Cell Membrane Equations

Ensembles of membrane proteins as statistical mixed-signal computers

Evaluation of approximate stochastic Hodgkin-Huxley models

Numeric Model of Power Linear Ordinary Differential Equation

Scalable Differential Analysis of Process Algebra Models

Semi-Markov Models for Brownian Dynamics Permeation in Biological Ion Channels

Uniformization Method for Solving Cardiac Electrophysiology Models Based on the Markov-Chain Formulation

On the channel-sensitive delay behavior of LIFO-backpressure

An Efficient Method for Modeling Kinetic Behavior of Channel Proteins in Cardiomyocytes

Similar Documents

An Efficient Method for Modeling Kinetic Behavior of Channel Proteins in Cardiomyocytes

A Second-Order Algorithm for Solving Dynamic Cell Membrane Equations

Ensembles of membrane proteins as statistical mixed-signal computers

Evaluation of approximate stochastic Hodgkin-Huxley models

Numeric Model of Power Linear Ordinary Differential Equation

Scalable Differential Analysis of Process Algebra Models

Semi-Markov Models for Brownian Dynamics Permeation in Biological Ion Channels

Uniformization Method for Solving Cardiac Electrophysiology Models Based on the Markov-Chain Formulation

On the channel-sensitive delay behavior of LIFO-backpressure

An Efficient Method for Modeling Kinetic Behavior of Channel Proteins in Cardiomyocytes