NDLI: Spatially Resolved Measurement of Dissolved Oxygen in Multistream Microfluidic Devices

Content Provider	IEEE Xplore Digital Library
Author	Nock, V. Blaikie, R.J.
Copyright Year	2001
Abstract	Dissolved oxygen (DO) is an important parameter with significant effect on cellular development and function. Micron-scale laminar flow and hydrodynamic focusing provide ideal tools for the generation of controlled chemical micro-environments and their application as stimuli to cells. In this paper, we demonstrate the generation and characterization of multistream laminar flow and hydrodynamically focused sample streams with defined dissolved oxygen concentrations on chip. A solid-state oxygen sensor layer was integrated into PDMS-based microchannels and calibrated. Several combinations of sample and buffer streams with concentrations ranging from 0 to 34 mg/l DO were generated and measured for up to three independent parallel flow streams. In addition, diffusion-based stream broadening measured with the sensor was used to determine the coefficient of diffusion of O₂ in the flow medium. The devices have the potential to provide novel insights into cell biology and improve the relevance of in vitro cell assays.
Sponsorship	IEEE Sensors Council
Starting Page	1813
Ending Page	1819
Page Count	7
File Size	741186
File Format	PDF
ISSN	1530437X
Volume Number	10
Issue Number	12
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-12-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Oxygen Microfluidics Fluid flow measurement Semiconductor device measurement Hydrodynamics Character generation Solid state circuits Chemical sensors Sensor phenomena and characterization Microchannel spatial measurement Hydrodynamic focusing microfluidics optical oxygen sensor PtOEPK/PS
Content Type	Text
Resource Type	Article
Subject	Instrumentation Electrical and Electronic Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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