NDLI: Segmentation of the Optic Disc in 3-D OCT Scans of the Optic Nerve Head

Content Provider	IEEE Xplore Digital Library
Author	Kyungmoo Lee Niemeijer, M. Garvin, M.K. Kwon, Y.H. Sonka, M. Abramoff, M.D.
Copyright Year	1982
Abstract	Glaucoma is the second leading ocular disease causing blindness due to gradual damage to the optic nerve and resultant visual field loss. Segmentations of the optic disc cup and neuroretinal rim can provide important parameters for detecting and tracking this disease. The purpose of this study is to describe and evaluate a method that can automatically segment the optic disc cup and rim in spectral-domain 3-D OCT (SD-OCT) volumes. Four intraretinal surfaces were segmented using a fast multiscale 3-D graph search algorithm. After surface segmentation, the retina in each 3-D OCT scan was flattened to ensure a consistent optic nerve head shape. A set of 15 features, derived from the segmented intraretinal surfaces and voxel intensities in the SD-OCT volume, were used to train a classifier that can determine which A-scans in the OCT volume belong to the background, optic disc cup and rim. Finally, prior knowledge about the shapes of the cup and rim was incorporated into the system using a convex hull-based approach. Two glaucoma experts annotated the cup and rim area using planimetry, and the annotations of the first expert were used as the reference standard. A leave-one-subject-out experiment on 27 optic nerve head-centered OCT volumes (14 right eye scans and 13 left eye scans from 14 patients) was performed. Two different types of classification methods were compared, and experimental results showed that the best performing method had an unsigned error for the optic disc cup of 2.52 ? 0.87 pixels (0.076 ? 0.026 mm) and for the neuroretinal rim of 2.04 ? 0.86 pixels (0.061 ? 0.026 mm). The interobserver variability as indicated by the unsigned border positioning difference between the second expert observer and the reference standard was 2.54 ? 1.03 pixels (0.076 ? 0.031 mm for the optic disc cup and 2.14 ? 0.80 pixels (0.064 ? 0.024 mm for the neuroretinal rim. The unsigned error of the best performing method was not significantly different (p > 0.2) from the interobserver variability.
Sponsorship	IEEE Engineering in Medicine and Biology Society IEEE Nuclear and Plasma Sciences Society IEEE Signal Processing Society IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society
Page Count	10
File Size	1302316
Starting Page	159
Ending Page	168
File Format	PDF
ISSN	02780062
Volume Number	29
Issue Number	1
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Cities and towns Biomedical optical imaging Diseases Blindness Shape Optical losses Retina Oncology Biomedical imaging Head spectral-domain optical coherence tomography (OCT) Glaucoma multiscale 3-D graph search neuroretinal rim optic disc optic disc cup optic nerve head (ONH)
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering Computer Science Applications Radiological and Ultrasound Technology Software

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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