NDLI: Drain Current Centric Modality: Instrumentation and Evaluation of ISFET for Monitoring Myocardial Ischemia Like Variations in pH and Potassium Ion Concentration

Content Provider	IEEE Xplore Digital Library
Author	Rai, P. Soyoun Jung Taeksoo Ji Varadan, V.K.
Copyright Year	2001
Abstract	Variations in concentrations of ions in biological systems can be important events in the onset of a physiological disorder. In an episode of myocardial ischemia, acidosis and elevation of potassium ion concentration has been observed in the extra-cellular matrix of the myocardium. As a spectrum of markers, they can help detect onset of ischemia as well as infarctions. In this study, Flexible Organic Ion-Sensitive Field-Effect Transistors (ISFETs) have been characterized to detect Ischemia-like variations in pH and potassium ion concentration. Detection capabilities, of the sensors, have been shown as pure chemical concentration to current signal transduction of the ISFET. Independent of peripheral amplifier-converter circuits, they are standalone sensors. The sensors have been evaluated for their sensitivity and signal resolution. Calibration expression, following a thermo-electric model for device operation, represents an explicit relations between transistor drain current and ion concentrations. Signal conditioning, by normalization, has been attempted to make the calibration expression explicit in ion-concentration. Finally a reliable detection strategy, in differential mode, is proposed for a reference electrode free device.
Sponsorship	IEEE Sensors Council
Starting Page	1987
Ending Page	1995
Page Count	9
File Size	773927
File Format	PDF
ISSN	1530437X
Volume Number	9
Issue Number	12
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-12-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Instruments Myocardium Ischemic pain Chemical sensors Sensor phenomena and characterization Calibration Biological systems Biomedical monitoring Active matrix organic light emitting diodes FETs site-binding-model Biosensor calibration flexible electronics ion-sensitive field-effect transistor (ISFET) myocardial ischemia (MI) OTFT pH potassium
Content Type	Text
Resource Type	Article
Subject	Instrumentation Electrical and Electronic Engineering

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