NDLI: Temporal Lobe Epilepsy: Anatomical and Effective Connectivity

Content Provider	IEEE Xplore Digital Library
Author	Cadotte, A.J. Mareci, T.H. DeMarse, T.B. Parekh, M.B. Rajagovindan, R. Ditto, W.L. Talathi, S.S. Dong-Uk Hwang Carney, P.R.
Copyright Year	2001
Abstract	While temporal lobe epilepsy (TLE) has been treatable with anti-seizure medications over the past century, there still remain a large percentage of patients whose seizures remain untreatable pharmacologically. To better understand and treat TLE, our laboratory uses several in vivo analytical techniques to estimate connectivity in epilepsy. This paper reviews two different connectivity-based approaches with an emphasis on application to the study of epilepsy. First, we present effective connectivity techniques, such as Granger causality, that has been used to assess the dynamic directional relationships among brain regions. These measures are used to better understand how seizure activity initiates, propagates, and terminates. Second, structural techniques, such as magnetic resonance imaging, can be used to assess changes in the underlying neural structures that result in seizure. This paper also includes in vivo epilepsy-centered examples of both effective and anatomical connectivity analysis. These analyses are performed on data collected in vivo from a spontaneously seizing animal model of TLE. Future work in vivo on epilepsy will no doubt benefit from a fusion of these different techniques. We conclude by discussing the interesting possibilities, implications, and challenges that a unified analysis would present.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	10
File Size	1589143
Starting Page	214
Ending Page	223
File Format	PDF
ISSN	15344320
Volume Number	17
Issue Number	3
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-06-01
Publisher Place	U.S.A.
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Temporal lobe Epilepsy Biomedical engineering Biomedical imaging In vivo Magnetic resonance imaging Magnetic analysis Hippocampus Medical treatment Laboratories temporal lobe epilepsy (TLE) Connectivity diffusion weighted imaging Granger causality (GC) magnetic resonance imaging (MRI)
Content Type	Text
Resource Type	Article
Subject	Neuroscience Rehabilitation Internal Medicine Biomedical Engineering Computer Science Applications

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