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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Hsun-Hsien Chang Moura, J.M.F. Wu, Y.L. Chien Ho |
| Copyright Year | 1982 |
| Abstract | Contrast-enhanced magnetic resonance imaging (MRI) is useful to study the infiltration of cells in vivo. This research adopts ultrasmall superparamagnetic iron oxide (USPIO) particles as contrast agents. USPIO particles administered intravenously can be endocytosed by circulating immune cells, in particular, macrophages. Hence, macrophages are labeled with USPIO particles. When a transplanted heart undergoes rejection, immune cells will infiltrate the allograft. Imaged by T2*-weighted MRI, USPIO-labeled macrophages display dark pixel intensities. Detecting these labeled cells in the image facilitates the identification of acute heart rejection. This paper develops a classifier to detect the presence of USPIO-labeled macrophages in the myocardium in the framework of spectral graph theory. First, we describe a USPIO-enhanced heart image with a graph. Classification becomes equivalent to partitioning the graph into two disjoint subgraphs. We use the Cheeger constant of the graph as an objective functional to derive the classifier. We represent the classifier as a linear combination of basis functions given from the spectral analysis of the graph Laplacian. Minimization of the Cheeger constant based functional leads to the optimal classifier. Experimental results and comparisons with other methods suggest the feasibility of our approach to study the rejection of hearts imaged by USPIO-enhanced MRI. |
| Sponsorship | IEEE Engineering in Medicine and Biology Society IEEE Nuclear and Plasma Sciences Society IEEE Signal Processing Society IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society |
| Page Count | 12 |
| File Size | 933583 |
| Starting Page | 1095 |
| Ending Page | 1106 |
| File Format | |
| ISSN | 02780062 |
| Volume Number | 27 |
| Issue Number | 8 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2008-08-01 |
| Publisher Place | U.S.A. |
| Access Restriction | One Nation One Subscription (ONOS) |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Heart Magnetic resonance imaging In vivo Iron Displays Pixel Myocardium Graph theory Spectral analysis Laplace equations ultrasmall superparamagnetic iron oxide (USPIO)-enhanced MRI Acute heart rejection cardiac magnetic resonance imaging (MRI) Cheeger constant classification classifier contrast agents graph cut graph Laplacian spectral graph theory Cardiac magnetic resonance imaging (cardiac MRI) USPIO-enhanced MRI acute heart rejection |
| Content Type | Text |
| Resource Type | Article |
| Subject | Electrical and Electronic Engineering Computer Science Applications Radiological and Ultrasound Technology Software |
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