NDLI: Dynamics modeling and analysis of inkjet technology-based oligo DNA microarray spotting

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Dynamics modeling and analysis of inkjet technology-based oligo DNA microarray spotting

Content Provider	IEEE Xplore Digital Library
Author	Mingjun Zhang Ou Ma Xiumin Diao
Copyright Year	2004
Abstract	Oligo deoxyribonucleic-acid (DNA) microarrays are fabricated through in-situ chemical synthesis. Contact and fluid dynamics contribute to this process. To produce high-quality oligo DNA microarrays, it is important to well understand the dynamics of the fabrication process. Much work has been done in understanding the chemistry principles. However, few studies have been conducted from the mechanics point of view. This paper proposes a contact dynamics model of inkjet technology-based oligo DNA microarray spotting process. The proposed dynamics model can reasonably well explain the dynamics of the oligo DNA microarray spotting process. Note to Practitioners-This research was motivated by the need to develop a dynamics model for analyzing the inkjet technology-based oligo deoxyribonucleic-acid (DNA) microarray spotting process. Modeling techniques for micro/nanoscale dynamics have not been well established in the open literature. This case study shows how this can be done for DNA spotting dynamics. Contact dynamics, electrostatic forces, viscous forces, and van der Waals forces have all been considered in this study. The method may be extended to model and analyze the dynamics of other biological particle spotting processes as well.
Sponsorship	IEEE Robotics and Automation Society
Starting Page	159
Ending Page	168
Page Count	10
File Size	912252
File Format	PDF
ISSN	15455955
Volume Number	3
Issue Number	2
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-04-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	DNA Chemical technology Fabrication Fluid dynamics Chemical analysis Nanobioscience Biological system modeling Genomics Bioinformatics Printing modeling Contact dynamics deoxyribonucleic-acid (DNA) chips microarrays microfabrication micro/nanoscale dynamics
Content Type	Text
Resource Type	Article
Subject	Control and Systems Engineering Electrical and Electronic Engineering

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