NDLI: Elastic scattering and light transport in three-dimensional collagen gel constructs: a mathematical model and computer Simulation approach

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Elastic scattering and light transport in three-dimensional collagen gel constructs: a mathematical model and computer Simulation approach

Content Provider	IEEE Xplore Digital Library
Author	Caria, A. Luca Bixio Kostyuk, O. Brown, R.A. Ruggiero, C.
Copyright Year	2002
Abstract	A mathematical modeling approach for elastic scattering and light propagation is presented, which can be used to obtain the scattering coefficient, the index of refraction, and the distribution of the collagen fibrils in a gel. Collagen fibrils can be realistically represented by small cylindrical particles. The analysis of the scattering of light by such particles provides the scattering coefficient. Light transport in multilayered tissues has been modeled and the collagen fibrils scattering coefficient has been considered as main input parameters. Assuming that a gel is composed of fibrils with the same diameter, it is possible to obtain all the input parameters of the model and, therefore, a simulated spectrum. This can be repeated for several diameters. Considering a gel composed of fibrils with different diameters, it is possible to obtain a best-fitting simulated spectrum as a weighted sum (least-square-error based) of the spectra corresponding to several fibril diameters, and, therefore, obtain an estimate of the percentages of fibrils of each diameter in the gel. Moreover, the scattering coefficient and refractive index, which are also provided by the model, are relevant parameters as they relate to tissue properties in their own right.
Sponsorship	IEEE Engineering in Medicine and Biology Society IEEE Systems, Man, and Cybernetics Society IEEE Nanotechnology Council IEEE Computational Intelligence Society IEEE Robotics and Automation Society IEEE Computer Society
Page Count	5
File Size	313087
Starting Page	85
Ending Page	89
File Format	PDF
ISSN	15361241
Volume Number	3
Issue Number	2
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-06-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Light scattering Mathematical model Computer simulation Particle scattering Optical scattering Optical refraction Scattering parameters Refractive index Connective tissue Electronic switching systems
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Bioengineering Electrical and Electronic Engineering Biomedical Engineering Computer Science Applications Biotechnology Pharmaceutical Science

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