NDLI: Accessing the tonotopic organization of the ventral cochlear nucleus by intranuclear microstimulation

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Accessing the tonotopic organization of the ventral cochlear nucleus by intranuclear microstimulation

Content Provider	IEEE Xplore Digital Library
Author	McCreery, D.B. Shannon, R.V. Moore, J.K. Chatterjee, M.
Copyright Year	1993
Abstract	This study is part of a program to develop an auditory prosthesis for the profoundly deaf, based on multichannel microstimulation in the cochlear nucleus. The functionality of such a device is dependent on its ability to access the tonotopic axis of the human ventral cochlear nucleus in an orderly fashion. In these studies, the authors utilized the homologies between the human and feline ventral cochlear nuclei and the known tonotopic organization of the central nucleus of the inferior colliculus (IC). In anesthetized cats, stimuli were delivered to three or four locations along the dorsal-to-ventral axis of the posteroventral cochlear nucleus (PVCN), and for each stimulus location, the authors recorded the multiunit neuronal activity and the field potentials at 20 or more locations along the dorsolateral-ventromedial (tonotopic) axis of the IC. The current source-sink density (CSD), which delimits regions of neuronal activity, was computed from the sequence of field potentials recorded along this axis. The multiunit activity and the CSD analysis both showed that the tonotopic organization of the PVCN can be accessed in an orderly manner by intranuclear microstimulation in several regions of the PVCN, using the range of stimulus pulse amplitudes that have been shown in previous studies to be noninjurious during prolonged intranuclear microstimulation via chronically implanted microelectrodes. The authors discuss the applicability of these findings to the design of clinical auditory prostheses for implantation into the human cochlear nucleus.
Sponsorship	IEEE Computer Society
Starting Page	391
Ending Page	399
Page Count	9
File Size	931447
File Format	PDF
ISSN	10636528
Volume Number	6
Issue Number	4
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1998-12-01
Publisher Place	U.S.A.
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electrodes Humans Prosthetics Auditory system Cochlear implants Microelectrodes Acoustic arrays Neurons Deafness Cats
Content Type	Text
Resource Type	Article
Subject	Engineering

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