NDLI: A Compact in-House Multi-Particle Cyclotron for Production of Radionuclides and Labeled Compounds for Medical Use

Content Provider	IEEE Xplore Digital Library
Author	Tilbury, R. S. Gelbard, A. S. McDonald, J. M. Benua, R. S. Laughlin, J. S.
Copyright Year	1963
Abstract	The Sloan-Kettering cyclotron located with covered access to two large hospitals, Memorial Hospital for Cancer and the New York Hospital, can accelerate deuterons to 8 MeV, protons and He-4 ions to 15 MeV and He-3 iohs to 23 MeV. A large number of radionuclides can be produced with these four particles and many compounds of physiological significance may be labeled. Methods will be described for the production of 15O as O2, CO and CO2 11C as CO, CO2, HCN, and other precursors for organic synthesis; 13N as N2, NO3-, NH4+ and 13N-labeled L-amino acids; 18F as NaF; 52Fe as ferrous citrate; 38K as KC1. Yields will be discussed, as well as the uses to which these radio indicators are put. The use of radioisotopes carbon-11, nitrogen-13 and fluorine-18 enables one to label compounds of true physiological or biochemical significance, and the concurrent development of instrumentation to quantitatively detect the localization of such compounds in the human body offers the opportunity to study phenomena heretofore impossible in the intact human, in a safe, non-invasive way. Examples of compounds which can be studied in this way are hormones, e.g. estradiol, for detection of breast cancer, amino acids for the detection of protein synthesis in tumors and the pancreas, precursors of DNA and RNA for the detection of abnormal cell growth, drugs related to neural disorders, e.g. haloperidol in schizophrenia.
Sponsorship	IEEE Nuclear and Plasma Sciences Society Computer Applications in Nuclear and Plasma Sciences (CANPS) Lawrence Berkeley Lab. Lawrence Livermore Nat. Lab. APS College of William and Mary Continuous Electron Beam Accelerator Facility NASA Defence Nuclear Agency Sandia National Laboratories Jet Propulsion Laboratory Brookhaven Nat. Lab. Lawrence Livermore Nat. Lab IEEE/NPPS Radiat. Effects Committee Defence Nuclear Agency/DoD Sandia National Laboratories/DOE Jet Propulsion Laboratory/NASA Phillips Lab./DoD
Starting Page	1729
Ending Page	1732
Page Count	4
File Size	575491
File Format	PDF
ISSN	00189499
Volume Number	26
Issue Number	1
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1979-02-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Cyclotrons Production Hospitals Cancer detection Humans Acceleration Protons Radioactive materials Instruments Biochemistry
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Electrical and Electronic Engineering Nuclear Energy and Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Production of Radioisotopes in the ORNL 86-Inch Cyclotron

Operation and Performance of a Compact, Isochronous Cyclotron

A Compact Cyclotron C-30 for Medical Isotopes Production

Novel compact cyclotrons for production of radionucleds.

Production of Medical Radionuclides with a 24 MeV Proton Cyclotron

Use of an Isochronous Cyclotron for Neutron Tie-of-Flight Experimentation

Compact Superconducting Cyclotrons for Neutron Therapy

Cyclotron Production of No-Carrier-Added Medical Radionuclides

Status Report on the Nirs-Chiba Isochronous Cyclotron Facility

A Compact in-House Multi-Particle Cyclotron for Production of Radionuclides and Labeled Compounds for Medical Use

Similar Documents

Production of Radioisotopes in the ORNL 86-Inch Cyclotron

Operation and Performance of a Compact, Isochronous Cyclotron

A Compact Cyclotron C-30 for Medical Isotopes Production

Novel compact cyclotrons for production of radionucleds.

Production of Medical Radionuclides with a 24 MeV Proton Cyclotron

Use of an Isochronous Cyclotron for Neutron Tie-of-Flight Experimentation

Compact Superconducting Cyclotrons for Neutron Therapy

Cyclotron Production of No-Carrier-Added Medical Radionuclides

Status Report on the Nirs-Chiba Isochronous Cyclotron Facility

A Compact in-House Multi-Particle Cyclotron for Production of Radionuclides and Labeled Compounds for Medical Use