NDLI: Quantity Determination of Magnetic Particles Intravenously Administered to Mice Tissues Using Magnetization Measurements

Content Provider	IEEE Xplore Digital Library
Author	Kishimoto, M. Miyamoto, R. Oda, T. Yanagihara, H. Ohkohchi, N. Kita, E.
Copyright Year	1965
Abstract	This paper presents a method that has been developed to determine the quantity of accumulated magnetic particles in mice tissues using magnetization measurements. Dispersions of platelet Fe₃O₄ particles with the size of 30-50 nm and a saturation magnetization of ~80$ Am²/kg were intravenously administered to mice. Primary tissues were dried to measure the magnetization. The amounts of Fe₃O₄ particles accumulated in the tissues were obtained by dividing the magnetization of tissues by the magnetization of Fe₃O₄ particles under a magnetic field of 39.8 kA/m. A remarkable accumulation of particles was observed in the liver and the spleen, being supported by the observation of tissues using Prussian blue staining. Total Fe₃O₄ particles accumulated in primary tissues were ~38 -40 and 40-44 wt% against the particles in administered dispersions with 3 and 0.4 wt% contents, respectively. The method developed in this paper is considered to be effective for verifying magnetic hyperthermia and thermoablation therapies, in which the quantity of accumulated particles directly reflects the heating power required for those therapies.
Sponsorship	IEEE Magnetics Society
Starting Page	1
Ending Page	6
Page Count	6
File Size	1206090
File Format	PDF
ISSN	00189464
Volume Number	51
Issue Number	10
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetization Atmospheric measurements Particle measurements Liver Saturation magnetization Mice Magnetic field measurement magnetization Accumulation administration Fe3O4 particles
Content Type	Text
Resource Type	Article
Subject	Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering

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