NDLI: Variable Ventilation as a Diagnostic Tool for the Injured Lung

Content Provider	IEEE Xplore Digital Library
Author	Smith, B.J. Bates, J.H.T.
Copyright Year	1964
Abstract	Mechanical ventilation of patients with acute respiratory distress syndrome (ARDS) is a necessary life support measure which may lead to ventilator-induced lung injury, a complication that can be reduced or ameliorated by using appropriate tidal volumes and positive end-expiratory pressures. However, the optimal mechanical ventilation parameters are almost certainly different for each patient, and will vary with time as the injury status of the lung changes. In order to optimize mechanical ventilation in an individual ARDS patient, therefore, it is necessary to track the manner in which injury status is reflected in the mechanical properties of the lungs. Accordingly, we developed an algorithm for assessing the time-dependent manner in which different lung regions open (recruit) and close (derecruit) as a function of the pressure waveform that is applied to the airways during mechanical ventilation. We used this algorithm to test the notion that variable ventilation provides the dynamic perturbations in lung volume necessary to accurately identify recruitment/derecruitment dynamics in the injured lung. We performed this test on synthetic pressure and flow data generated with established numerical models of lung function corresponding to both healthy mice and mice with lung injury. The data were generated by subjecting the models to a variety of mechanical ventilation regimens including variable ventilation. Our results support the hypothesis that variable ventilation can be used as a diagnostic tool to identify the injury status of the lung in ARDS.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	8
File Size	1269234
Starting Page	2106
Ending Page	2113
File Format	PDF
ISSN	00189294
Volume Number	62
Issue Number	9
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Lungs Atmospheric modeling Ventilation Estimation Data models Mice Injuries recruitment Computational model derecruitment diagnostic tool optimal mechanical ventilation
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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