NDLI: Generation of the Probabilistic Template of Default Mode Network Derived from Resting-State fMRI

Content Provider	IEEE Xplore Digital Library
Author	Defeng Wang Youyong Kong Chu, W.C.W. Tam, C.W.C. Lam, L.C.W. Yilong Wang Northoff, G. Mok, V.C.T. Yongjun Wang Lin Shi
Copyright Year	1964
Abstract	Default-mode network (DMN) has become a prominent network among all large-scale brain networks which can be derived from the resting-state fMRI (rs-fMRI) data. Statistical template labeling the common location of hubs in DMN is favorable in the identification of DMN from tens of components resulted from the independent component analysis (ICA). This paper proposed a novel iterative framework to generate a probabilistic DMN template from a coherent group of 40 healthy subjects. An initial template was visually selected from the independent components derived from group ICA analysis of the concatenated rs-fMRI data of all subjects. An effective similarity measure was designed to choose the best-fit component from all independent components of each subject computed given different component numbers. The selected DMN components for all subjects were averaged to generate an updated DMN template and then used to select the DMN for each subject in the next iteration. This process iterated until the convergence was reached, i.e., the overlapping region between the DMN areas of the current template and the one generated from the previous stage is more than 95%. By validating the constructed DMN template on the rs-fMRI data from another 40 subjects, the generated probabilistic DMN template and the proposed similarity matching mechanism were demonstrated to be effective in automatic selection of independent components from the ICA analysis results.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Starting Page	2550
Ending Page	2555
Page Count	6
File Size	421217
File Format	PDF
ISSN	00189294
Volume Number	61
Issue Number	10
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electronic mail Biomedical imaging Educational institutions Magnetic resonance imaging Probabilistic logic Materials Brain template Brain network default mode network (DMN) resting-state fMRI (rs-fMRI)
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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