NDLI: Modeling Biology With HDL Languages: A First Step Toward a Genetic Design Automation Tool Inspired From Microelectronics

Content Provider	IEEE Xplore Digital Library
Author	Gendrault, Y. Madec, M. Lallement, C. Haiech, J.
Copyright Year	1964
Abstract	Nowadays, synthetic biology is a hot research topic. Each day, progresses are made to improve the complexity of artificial biological functions in order to tend to complex biodevices and biosystems. Up to now, these systems are handmade by bioengineers, which require strong technical skills and leads to nonreusable development. Besides, scientific fields that share the same design approach, such as microelectronics, have already overcome several issues and designers succeed in building extremely complex systems with many evolved functions. On the other hand, in systems engineering and more specifically in microelectronics, the development of the domain has been promoted by both the improvement of technological processes and electronic design automation tools. The work presented in this paper paves the way for the adaptation of microelectronics design tools to synthetic biology. Considering the similarities and differences between the synthetic biology and microelectronics, the milestones of this adaptation are described. The first one concerns the modeling of biological mechanisms. To do so, a new formalism is proposed, based on an extension of the generalized Kirchhoff laws to biology. This way, a description of all biological mechanisms can be made with languages widely used in microelectronics. Our approach is therefore successfully validated on specific examples drawn from the literature.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	10
File Size	639975
Starting Page	1231
Ending Page	1240
File Format	PDF
ISSN	00189294
Volume Number	61
Issue Number	4
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biological system modeling Microelectronics Mathematical model Synthetic biology Integrated circuit modeling Hardware design languages synthetic biology Biological models computer-aided engineering design flow hardware description languages
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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