NDLI: An experimental study on the stiffness of size-isolated microbubbles using atomic force microscopy

Content Provider	IEEE Xplore Digital Library
Author	Chen, C.C. Shih-Ying Wu Finan, J.D. Morrison III, B. Konofagou, E.E.
Copyright Year	1986
Abstract	To fully assess contrast-enhanced acoustic bioeffects in diagnostic and therapeutic procedures, the mechanical properties of microbubbles need to be considered. In the present study, direct measurements of the microbubble stiffness were performed using atomic force microscopy by applying nanoscale compressions (up to 25 nN/s) on size-isolated, lipidcoated microbubbles (diameter ranges of 4 to 6 μm and 6 to 8 μm). The stiffness was found to lie between 4 and 22 mN/m and to decrease exponentially with the microbubble size within the diameter range investigated. No cantilever spring constant effect was found on the measured stiffness. The Young's modulus of the size-isolated microbubbles used in our study ranged between 0.4 and 2 MPa. Microstructures on the surface of the microbubbles were found to influence the overall microbubble elasticity. Our results indicated that more detailed theoretical models are needed to account for the size-dependent microbubble mechanical properties to accurately predict their acoustic behavior. The findings provided useful insights into guidance of cavitation-induced drug and gene delivery and could be used as part of the framework in studies on the shear stresses induced on the blood vessel walls by oscillating microbubbles.
Page Count	11
File Size	774103
Starting Page	524
Ending Page	534
File Format	PDF
ISSN	08853010
Volume Number	60
Issue Number	3
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Force Springs Glass Microscopy Force measurement Phase locked loops Suspensions
Content Type	Text
Resource Type	Article
Subject	Acoustics and Ultrasonics Instrumentation Electrical and Electronic Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

An Experimental Study on the Stiffness of Size-Isolated Microbubbles Using Atomic Force Microscopy

An experimental study on the apparent stiffness of size-isolated microbubbles used for blood-brain barrier opening applications

Investigation of crossed SAW fields by scanning acoustic force microscopy

Modeling phase noise in multifunction subassemblies

An automatic tracking system for phase-noise measurement

A low noise and ultra-narrow bandwidth frequency-locked loop based on the beat method

An improved phase-locked loop method for automatic resonance frequency tracing based on static capacitance broadband compensation for a high-power ultrasonic transducer

Ultrasound array transmitter architecture with high timing resolution using embedded phase-locked loops

A study on phase-noise reduction method in phase-locked loop systems

An experimental study on the stiffness of size-isolated microbubbles using atomic force microscopy

Similar Documents

An Experimental Study on the Stiffness of Size-Isolated Microbubbles Using Atomic Force Microscopy

An experimental study on the apparent stiffness of size-isolated microbubbles used for blood-brain barrier opening applications

Investigation of crossed SAW fields by scanning acoustic force microscopy

Modeling phase noise in multifunction subassemblies

An automatic tracking system for phase-noise measurement

A low noise and ultra-narrow bandwidth frequency-locked loop based on the beat method

An improved phase-locked loop method for automatic resonance frequency tracing based on static capacitance broadband compensation for a high-power ultrasonic transducer

Ultrasound array transmitter architecture with high timing resolution using embedded phase-locked loops

A study on phase-noise reduction method in phase-locked loop systems

An experimental study on the stiffness of size-isolated microbubbles using atomic force microscopy