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Studies on the purification and characterization of dipeptidylaminopeptidase, 4
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Schulz, H. Barth, A. Neubert, K. |
| Organization | The National Aeronautics and Space Administration (NASA) |
| Copyright Year | 1974 |
| Abstract | IN THE MICROSOMAL OF PIG KIDNEYS, ASIDE FROM PARTICLE-BOUND AMINOPEPTIDASE (EC 3.4.1.2), A DIPEPTIDYL AMINOPEPTIDASE IS OBSERVED WHICH, UPON SOLUBILIZATION, FRACTIONATED AMMONIUM SULFATE PRECIPITATION AND COLUMN CHROMATOGRAPHY, CAN BE SEPARATED FROM THE AMINOPEPTIDASE, AND ISOLATED PURELY BY DISC ELECTROPHORESIS. IT IS ASSUMED THAT DIPEPTIDYL AMINOPEPTIDASE IV POSSESSES TWO DIFFERENT SPECIFITIES FOR SUBSTRATES WITH THE SEQUENCE L-AS-L ALA-R, AND FOR SUBSTRATES WITH THE SEQUENCE L-AS-L-PRO-R. THE ENZYMATIC HYDROLYSIS OF THE TWO SUBSTRATE SEQUENCES DIFFERS BY THE POSITION OF THE OPTIMA AND THE INHIBITION BY DFP. WHEREAS CATIONS HAVE A RELATIVELY WEAK INFLUENCE ON THE ENZYMATIC ACTIVITY OF DIPEPTIDYL AMINOPEPTIDASE IV, THE INFLUENCE OF ANIONS PROVED TO BE SIGNIFICANT. |
| File Size | 754397 |
| File Format | |
| Alternate Webpage(s) | http://www.archive.org/details/nasa_techdoc_19750003522 |
| Archival Resource Key | ark:/13960/t3rv18w3v |
| Language | English |
| Publisher Date | 1974-11-01 |
| Access Restriction | Open |
| Subject Keyword | Earth Ionosphere Radio Navigation Time Lag Time Measurement Ats Electrons Faraday Effect Position (location) Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
