NDLI: Aligned and electrospun piezoelectric polymer fiber assembly and scaffold

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Aligned and electrospun piezoelectric polymer fiber assembly and scaffold

Content Provider	NASA Technical Reports Server (NTRS)
Copyright Year	2015
Description	A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface; electrospinning a first substantially aligned polymer fiber layer onto the first surface; providing a second pre-electroded substrate surface; electrospinning a second substantially aligned polymer fiber layer onto the second surface; and, retaining together the layered surfaces with a clamp and/or an adhesive compound.
File Size	1996218
Page Count	15
File Format	PDF
Alternate Webpage(s)	http://archive.org/details/NASA_NTRS_Archive_20150007182
Archival Resource Key	ark:/13960/t6c29wt3x
Language	English
Publisher Date	2015-04-14
Access Restriction	Open
Subject Keyword	Electrodes Electroactive Polymers Patents Ferroelectricity Tissue Engineering Stem Cells Piezoelectricity Substrates Fibers Cell Culturing Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science
Content Type	Text
Resource Type	Patent

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