NDLI: Update of the bisphosphonate iss flight experiment

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Update of the bisphosphonate iss flight experiment

Content Provider	NASA Technical Reports Server (NTRS)
Author	Kohri, Kenjiro Shapiro, Jay Evans, Harlan Moralez, Gilbert Lang Sr., Thomas Keyak, Joyce Smith, Scott M. LeBlanc, Adrian Sibonga, Jean Nakamura, Toshitaka Jones, Jeffrey Ohshima, Hiroshi Matsumoto, Toshio Spector, Elisabeth Ploutz-Snyder, Robert Shackelford, Linda
Copyright Year	2014
Description	The bisphosphonate study is an international collaboration between the NASA and JAXA space agencies to investigate the potential value of antiresorptive drugs to mitigate the well-established bone changes associated with long-duration spaceflight. Our hypothesis is that an antiresorptive drug in combination with in-flight exercise will ameliorate bone loss and hypercalcuria during long-duration spaceflight. We have completed data analysis for 7 crewmembers treated with alendronate during flight and 3 of 10 controls without treatment. We previously reported the pre/postflight changes in bone density and the pre versus in-flight changes in various biomarkers in crewmembers taking alendronate during flight. The purpose of this report is to compare these results with the 12- month follow-up data. The table below presents these data as a percentage change from baseline either immediately postflight or in-flight (biochemical markers) with a 1-year follow-up.
File Size	13170
Page Count	1
File Format	PDF
Alternate Webpage(s)	http://archive.org/details/NASA_NTRS_Archive_20140003848
Archival Resource Key	ark:/13960/t2q57m37d
Language	English
Publisher Date	2014-02-10
Access Restriction	Open
Subject Keyword	Aerospace Medicine Drugs Bone Mineral Content Spacecrews International Space Station Spaceborne Experiments Biomarkers Data Processing Long Duration Space Flight Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science
Content Type	Text
Resource Type	Article

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