NDLI: Dose response for chromosome aberrations in human lymphocytes and fibroblasts after exposure to very low doses of high let radiation

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Dose response for chromosome aberrations in human lymphocytes and fibroblasts after exposure to very low doses of high let radiation

Content Provider	NASA Technical Reports Server (NTRS)
Author	George, Kerry Hada, M. Cucinotta, Francis A.
Copyright Year	2011
Description	The relationship between biological effects and low doses of absorbed radiation is still uncertain, especially for high LET radiation exposure. Estimates of risks from low-dose and low-dose-rates are often extrapolated using data from Japanese atomic bomb survivors with either linear or linear quadratic models of fit. In this study, chromosome aberrations were measured in human peripheral blood lymphocytes and normal skin fibroblasts cells after exposure to very low dose (1-20 cGy) of 170 MeV/u Si-28- ions or 600 MeV/u Fe-56-ions. Chromosomes were analyzed using the whole chromosome fluorescence in situ hybridization (FISH) technique during the first cell division after irradiation, and chromosome aberrations were identified as either simple exchanges (translocations and dicentrics) or complex exchanges (involving greater than 2 breaks in 2 or more chromosomes). The curves for doses above 10 cGy were fitted with linear or linear-quadratic functions. For Si-28- ions no dose response was observed in the 2-10 cGy dose range, suggesting a non-target effect in this range.
File Size	10354
Page Count	1
File Format	PDF
Alternate Webpage(s)	http://archive.org/details/NASA_NTRS_Archive_20110012285
Archival Resource Key	ark:/13960/t92859v2f
Language	English
Publisher Date	2011-01-01
Access Restriction	Open
Subject Keyword	Radiation Effects Skin Anatomy Blood Cells Cell Division Fluorescence Radiation Dosage Iron Isotopes Linear Energy Transfer Let Lymphocytes Silicon Isotopes Fibroblasts Linear Equations Chromosome Aberrations Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science
Content Type	Text
Resource Type	Article

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