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Versatile platform for nanotechnology based on circular permutations of chaperonin protein
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Copyright Year | 2010 |
| Description | The present invention provides chaperonin polypeptides which are modified to include N-terminal and C-terminal ends that are relocated from the central pore region to various different positions in the polypeptide which are located on the exterior of the folded modified chaperonin polypeptide. In the modified chaperonin polypeptide, the naturally-occurring N-terminal and C-terminal ends are joined together directly or with an intervening linker peptide sequence. The relocated N-terminal or C-terminal ends can be covalently joined to, or bound with another molecule such as a nucleic acid molecule, a lipid, a carbohydrate, a second polypeptide, or a nanoparticle. The modified chaperonin polypeptides can assemble into double-ringed chaperonin structures. Further, the chaperonin structures can organize into higher order structures such as nanofilaments or nanoarrays which can be used to produce nanodevices and nanocoatings. |
| File Size | 8965177 |
| Page Count | 149 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_20100040712 |
| Archival Resource Key | ark:/13960/t5t77cz94 |
| Language | English |
| Publisher Date | 2010-09-14 |
| Access Restriction | Open |
| Subject Keyword | Nanoparticles Proteins Permutations Patents Polypeptides Inventions Nanotechnology Covalent Bonds Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Patent |
