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Hemodynamic effects of midodrine after space flight in astronauts without orthostatic hypotension
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Waters, Wendy W. Ziegler, Michael G. Meck, Janice V. Platts, Steven H. |
| Copyright Year | 2006 |
| Description | Orthostatic hypotension and presyncope are common and potentially serious risks for astronauts returning from space. Susceptible subjects fail to generate an adequate adrenergic response to upright posture. The -1 adrenergic agonist, midodrine, may be an effective countermeasure. We tested the hypothesis that midodrine would have no negative hemodynamic effect on healthy astronauts returning from space. Five male astronauts participated in preflight and postflight tilt testing on a control flight as well as on the test flights, where midodrine (10 mg, orally) was administered after landing, approximately 1 hour before testing. None of these astronauts exhibited orthostatic hypotension or presyncope before or after either flight. Midodrine did not cause any untoward reactions in these subjects before or after flight, in fact a modest beneficial effect was seen on postflight tachycardia (p=0.036). These data show that midodrine protected against post-spaceflight increases in heart rate, without having any adverse hemodynamic effects on non-presyncopal, male astronauts. Among these subjects, midodrine was a safe cardiovascular countermeasure. |
| File Size | 110997 |
| Page Count | 17 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_20080033572 |
| Archival Resource Key | ark:/13960/t6159jw43 |
| Language | English |
| Publisher Date | 2006-01-01 |
| Access Restriction | Open |
| Subject Keyword | Aerospace Medicine Cardiovascular System Gravitational Physiology Hemodynamic Responses Risk Pharmacology Return To Earth Space Flight Manned Space Flight Flight Stress Biology Hypotension Dizziness Tachycardia Gravitational Effects Hydrochlorides Countermeasures Orthostatic Tolerance Risk Management Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Article |
