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Immune function changes during a spaceflight-analog undersea mission
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Crucian, Brian Pierson, Duane Yetman, Deborah Stowe, Raymond Quiniarte, Heather Sams, Clarence Mehta, Satish |
| Copyright Year | 2008 |
| Description | There is ample evidence to suggest that space flight leads to immune system dysregulation. This may be a result of microgravity, confinement, physiological stress, radiation, environment or other mission-associated factors. It is attractive to utilize ground-based spaceflight analogs as appropriate to investigate this phenomenon. For spaceflight-associated immune dysregulation (SAID), the authors believe the most appropriate analogs might be NEEMO (short duration, Shuttle analog), Antarctic winter-over (long-duration, ISS analog) and the Haughton Mars Project in the Canadian Arctic (intermediate-duration). Each of these analogs replicate isolation, mission-associated stress, disrupted circadian rhythms, and other aspects of flight thought to contribute to SAID. To validate NEEMO as a flight analog with respect to SAID, a pilot study was conducted during the NEEMO-12 and 13 missions during 2007. Assays were performed that assessed immune status, physiological stress and latent viral reactivation. Blood and saliva samples were collected at pre-, mid-, and post-mission timepoints. |
| File Size | 890455 |
| Page Count | 1 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_20080010619 |
| Archival Resource Key | ark:/13960/t8pc7zp82 |
| Language | English |
| Publisher Date | 2008-02-04 |
| Access Restriction | Open |
| Subject Keyword | Aerospace Medicine Circadian Rhythms Bioassay Regulatory Mechanisms Biology Nasa Space Programs Leukocytes Hormones Manned Space Flight Blood Long Duration Space Flight Analogs Immune Systems Spacecrews International Space Station Space Missions Cells Biology Deoxyribonucleic Acid Bone Demineralization Space Flight Stress Microgravity Saliva Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Article |
