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Suppression of antigen-specific lymphocyte activation in simulated microgravity
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Pellis, Neal R. Pride, Michael W. Risin, Diana Cooper, David Brown, Eric L. |
| Copyright Year | 1999 |
| Description | Various parameters of immune suppression are observed in astronauts during and after spaceflight, and in isolated immune cells in true and simulated microgravity. Specifically, polyclonal activation of T cells is severely suppressed in true and simulated microgravity. These recent findings with various polyclonal activators suggests a suppression of oligoclonal lymphocyte activation in microgravity. We utilized rotating wall vessel (RWV) bioreactors that simulate aspects of microgravity for cell cultures to analyze three models of antigen-specific activation. A mixed-lymphocyte reaction (MLR), as a model for a primary immune response; a tetanus toxoid (TT) response and a B. burgdorferi (Bb) response, as models of a secondary immune response, were all suppressed in the RWV bioreactor. Our findings confirm that the suppression of activation observed with polyclonal models also encompasses oligoclonal antigen-specific activation. |
| File Size | 399994 |
| Page Count | 15 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_20000091532 |
| Archival Resource Key | ark:/13960/t8sb91b78 |
| Language | English |
| Publisher Date | 1999-01-01 |
| Access Restriction | Open |
| Subject Keyword | Immune Systems Antigens Physiological Effects Bioastronautics Immunology Gravitational Effects Gravitational Physiology Bioreactors Aerospace Medicine Space Flight Microgravity Physiological Responses Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Article |
