NDLI: Microcapsules and methods for making

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Microcapsules and methods for making

Content Provider	NASA Technical Reports Server (NTRS)
Copyright Year	1994
Description	This invention relates to methods for forming multi-lamellar microcapsules of both hydrophilic and hydrophobic immiscible liquid phases using several polymer/solvent systems. Liquid-Liquid diffusion and spontaneous emulsification are controlled by properly timed sequence exposures of immiscible phases in aqueous vehicles dispersed in hydrocarbon solvents containing small quantities of oil, co-surfactants, and glycerides. Water-in-oil and oil-in-water microcapsules are formed containing selected combinations of several types of drugs, co-encapsulated within fluid compartments inside the microcapsule. Commercial applications of the process and the resultant product relate to drug therapy for treating medical conditions such as cancer, circulatory conditions, and other conditions in which pharmaceuticals are advantageously targeted to specific organs, or delivered in combination with other pharmaceuticals. Small microcapsules may be delivered intravenously to diseased organs or clotted vessels. The use of multiple drugs within the same microcapsule structure provides advantages for applications such as chemoembolization treatments and may be used to deliver both chemotherapeutic drugs, against tumor cells, and an immuno-adjuvant or immunological stimulant to enhance the patient's immune response. Active forms of urokinase and other enzymes may be delivered without dilution to the local site of an embolism for dissolving the embolism. Thus, the invention has several potentially valuable commercial applications related to pharmaceutical and medical applications.
File Size	3856538
Page Count	93
File Format	PDF
Alternate Webpage(s)	http://archive.org/details/NASA_NTRS_Archive_19970018048
Archival Resource Key	ark:/13960/t3sv2hk5c
Language	English
Publisher Date	1994-12-02
Access Restriction	Open
Subject Keyword	Drugs Glycerides Embolisms Liquid Phases Pharmacology Exposure Physiological Responses Dilution Capsules Cells Biology Dissolving Patent Applications Cancer Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science
Content Type	Text
Resource Type	Patent

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