Loading...
Please wait, while we are loading the content...
Similar Documents
Gravity and animal embryos
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Wiley, Lynn M. |
| Copyright Year | 1989 |
| Description | Out of more than 4,500 rat hours in space there was only one experimental attempt (Cosmos 1129) at mating with an apparent absence of fertilization, implantation and subsequent development to term and partuition. Portions of this process were successfully flown, however, including the major portion of organogenesis in the rat (Cosmos 1524). These observations show that the cellular and molecular events underlying morphogenesis and differentiation in a small mammal can proceed normally in-utero under microgravity and other conditions encountered during short-duration flight. However, it is not known whether this situation will hold for larger mammals over several generations during extended missions that venture outside of near Earth. Furthermore, it is not understood why the previous attempt at obtaining copulation, fertilization and implantation in orbit failed but may be related to limitations of the rat habitat for meeting the preconditions for reproductive behavior. With respect to mammalian development it is important to appreciate that fertilization and development occur internally within the female and take a long time to complete and their success will, therefore, be contingent upon the maternal response to the space environment. One process central to development (the establishment of cell lines) is initiated prior to implantation by environmental asymmetries preceived by progenitor cells. These asymmetries appear to result from the formation of asymmetric cell-cell contacts and the concommitant development of an electrical axis across the progenitor cells. Other asymmetries were also documented. It is not known whether any of the known asymmetries perceived by progenitor cells are influenced by gravity vectors and/or by the maternal response to microgravity and other conditions encountered in space. |
| File Size | 239305 |
| Page Count | 4 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_19900004635 |
| Archival Resource Key | ark:/13960/t13n72781 |
| Language | English |
| Publisher Date | 1989-08-01 |
| Access Restriction | Open |
| Subject Keyword | Space Biology Gravitational Effects Fertility Space Commercialization Spaceborne Experiments Rats Differentiation Biology Microgravity Reproduction Biology Embryos Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Article |
