NDLI: Cardiac reserve during weightlessness simulation and shuttle flight

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Cardiac reserve during weightlessness simulation and shuttle flight

Content Provider	NASA Technical Reports Server (NTRS)
Author	Goldberger, A. L.
Copyright Year	1985
Description	Bedrest deconditioning is suspected to reduce cardiac function. However, quantitation of subtle decreases in cardiac reserve may be difficult. Normal subjects show considerable variability in heart rate response, reflected by a relatively broadband interbeat interval power spectrum. We hypothesized that the deconditioning effects of bedrest would induce narrowing of this spectrum, reflecting a reduction in the autonomically-modulated variability in heart rate. Ten aerobically conditioned men (average 35-50 years) underwent orthostatic tolerance testing with lower body negative pressure pre-bedrest and after 10 days of bedrest, while on placebo and after intravenous atropine. Spectra were derived by Fourier analysis of 128 interbeat interval data sets from subjects with sufficient numbers of beats during matched periods of the protocol. Data suggest that atropine unmasks the deconditioning effect of bedrest in athletic men, evidenced by a reduction in interbeat interval spectral power compared with placebo. Spectral analysis offers a new means of quantitating the effects of bedrest deconditioning and autonomic perturbations on cardiac dynamics.
File Size	986345
Page Count	32
File Format	PDF
Alternate Webpage(s)	http://archive.org/details/NASA_NTRS_Archive_19860020025
Archival Resource Key	ark:/13960/t01z92z6f
Language	English
Publisher Date	1985-10-01
Access Restriction	Open
Subject Keyword	Aerospace Medicine Heart Rate Physical Fitness Deconditioning Power Spectra Autonomic Nervous System Spectrum Analysis Atropine Fourier Analysis Intravenous Procedures Orthostatic Tolerance Bed Rest Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science
Content Type	Text
Resource Type	Technical Report

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