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Is fast fiber innervation responsible for increased acetylcholinesterase activity in reinnervating soleus muscles?
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Misulis, K. E. Dettbarn, W. D. |
| Copyright Year | 1985 |
| Description | An investigation was conducted as to whether the predominantly slow SOL, which is low in AChE activity, is initially reinnervated by axons that originally innervated fast muscle fibers with high AChE activity, such as those of the EDL. Local denervation of the SOL in the guinea pig was performed because this muscle is composed solely of slow (type I) fibers; thereby virtually eliminating the possibility of homologous muscle fast fiber innervation. The overshoot in this preparation was qualitatively similar to that seen with distal denervation in the guinea pig and local and distal denervation in the rat. Thus, initial fast fiber innvervation is not responsible for the patterns of change in AChE activity seen with reinnervation in the SOL. It is concluded that the neural control of AChe is different in these two muscles and may reflect specific differences in the characteristics of AChE regulation in fast and slow muscle. |
| File Size | 800016 |
| Page Count | 20 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_19850017797 |
| Archival Resource Key | ark:/13960/t7wm65b6q |
| Language | English |
| Publisher Date | 1985-01-01 |
| Access Restriction | Open |
| Subject Keyword | Peripheral Nervous System Neurotransmitters Enzyme Activity Guinea Pigs Nerves Rats Muscles Neuromuscular Transmission Cholinesterase Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Technical Report |
