Loading...
Please wait, while we are loading the content...
Similar Documents
Mutagenic screening of diamine monomers
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Fullenkamp, J. M. Graham, J. A. Noble, J. E. Gridley, J. A. Ross, W. D. Wininger, M. T. |
| Copyright Year | 1983 |
| Description | The effects of phenyl ring coupling moieties, of isomeric amine positions relative to the coupling groups, and of insertion of other coupling groups on the mutagenic response of a series of dianilines were investigated using the Ames Salmonella assay. Generally, S-9 metabolic activation from Aroclor-induced rat liver was required for mutagenic expression. The range of mutagenicity of steric isomers of several dianiline series was also investigated. No mutagenicity was found for purified samples of o,o' and m,p' isomers of methylene dianiline (MDA) and diaminobenzophenone, while varying degrees of mutagenicity were found for other isomers. The mutagenicity of "benzylogs" of MDA decreased as the degree of linear separation of the m,m' anilino groups by aromatic rings increased. Methylation and two-year storage increased mutagenic response in certain isomers of MDA. However, high performance liquid chromatography indicated there was no discernible change in m,p'-MDA samples aged under varied conditions over four months. Likewise, no change in mutagenicity was found. |
| File Size | 2013704 |
| Page Count | 108 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_19830013482 |
| Archival Resource Key | ark:/13960/t58d4r641 |
| Language | English |
| Publisher Date | 1983-02-01 |
| Access Restriction | Open |
| Subject Keyword | Diamines Screening Mutagens Toxicity Isomers Monomers Chromatography Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Technical Report |
