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Effect of central neurotropic substances on the hypophysisadrenal cortex system during immobilization of animals
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Ryzhenkov, V. Y. |
| Copyright Year | 1980 |
| Description | The immobilization of guinea pigs for 5, 12, 24 and 48 hours, by securing to a slab, results in a persistent rise of the blood plasma 17-oxycorticosteroid concentration. Repeated administration of phenobarbital (50 mg/kg) and of the sodium salt of gamma-oxybutyric acid (500 mg/kg), as well as the combined administration of central m- and n-cholinolytics with small doses of phenobarbital tends to inhibit activation of the adrenal cortex during 48 hour immobilization of the animals. Repeated administration of aminazine (20 mg/kg) tends to decrease activation of the adrenal cortex. The administration of reserpine (0.1-5 mg/kg) 12-18 hours before immobilization of guinea pigs increases the response of the hypophysis-adrenal cortex system. |
| File Size | 542129 |
| Page Count | 10 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_19800019481 |
| Archival Resource Key | ark:/13960/t13n6zm3x |
| Language | English |
| Publisher Date | 1980-05-01 |
| Access Restriction | Open |
| Subject Keyword | Physiological Effects Phenobarbital Guinea Pigs Central Nervous System Depressants Immobilization Pharmacology Neurotropism Adrenal Gland Hormone Metabolisms Endocrinology Stress Physiology Blood Plasma Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Technical Report |
