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Organic-Inorganic Hybrid Hollow Mesoporous Organosilica Nanoparticles for Efficient Ultrasound-Based Imaging and Controlled Drug Release
| Content Provider | Hindawi |
|---|---|
| Author | Qian, Xiaoqin Wang, Wenping Kong, Wentao Chen, Yu |
| Editor | Gu, Hongchen Chen |
| Copyright Year | 2014 |
| Abstract | A novel anticancer drug delivery system with contrast-enhanced ultrasound-imaging performance was synthesized by a typical hard-templating method using monodispersed silica nanoparticles as the templates, which was based on unique molecularly organic/inorganic hybrid hollow periodic mesoporous organosilicas (HPMOs). The highly dispersed HPMOs show the uniform spherical morphology, large hollow interior, and well-defined mesoporous structures, which are very beneficial for ultrasound-based theranostics. The obtained HPMOs exhibit excellent performances in contrast-enhanced ultrasonography both in vitro and in vivo and can be used for the real-time determination of the progress of lesion tissues during the chemotherapeutic process. Importantly, hydrophobic paclitaxel- (PTX-) loaded HPMOs combined with ultrasound irradiation show fast ultrasound responsiveness for controlled drug release and higher in vitro and in vivo tumor inhibition rates compared with free PTX and PTX-loaded HPMOs, which is due to the enhanced ultrasound-triggered drug release and ultrasound-induced cavitation effect. Therefore, the achieved novel HPMOs-based nanoparticle systems will find broad application potentials in clinically ultrasound-based imaging and auxiliary tumor chemotherapy. |
| Page Count | 8 |
| File Format | |
| ISSN | 16874110 |
| DOI | 10.1155/2014/972475 |
| Journal | Journal of Nanomaterials |
| Volume Number | 2014 |
| e-ISSN | 16874129 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2014-06-24 |
| Access Restriction | Open |
| Rights License | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology |
