NDLI: Small networks of expressed genes in the whole blood and relationships to profiles in circulating metabolites provide insights in inter-individual variability of feed efficiency in growing pigs

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Small networks of expressed genes in the whole blood and relationships to profiles in circulating metabolites provide insights in inter-individual variability of feed efficiency in growing pigs

Content Provider	Hyper Articles en Ligne (HAL)
Author	Juigné, Camille Becker, Emmanuelle Gondret, Florence
Abstract	Background: Feed efficiency is a research priority to support a sustainable meat production. It is recognized as a complex trait that integrates multiple biological pathways orchestrated in and by various tissues. This study aims to determine networks between biological entities to explain inter-individual variation of feed efficiency in growing pigs. Results: The feed conversion ratio (FCR), a measure of feed efficiency, and its two component traits, average daily gain and average daily feed intake, were obtained from 47 growing pigs from a divergent selection for residual feed intake and fed high-starch or high-fat high-fiber diets during 58 days. Datasets of transcriptomics (60 k porcine microarray) in the whole blood and metabolomics (1H-NMR analysis and target gas chromatography) in plasma were available for all pigs at the end of the trial. A weighted gene co-expression network was built from the transcriptomics dataset, resulting in 33 modules of coexpressed molecular probes. The eigengenes of eight of these modules were significantly (P ≤ 0.05) or tended to be (0.05
Related Links	https://hal.science/hal-04112110/file/cjuigne___wgcna_modules___preprint-1.pdf
Language	English
Publisher	HAL CCSD
Access Restriction	Open
Content Type	Text
Resource Type	Article
Subject	Chemistry Biochemistry, Genetics and Molecular Biology

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