NDLI: Direct Trifluoromethylation of Alcohols Using a Hypervalent Iodosulfoximine Reagent

Please wait, while we are loading the content...

Direct Trifluoromethylation of Alcohols Using a Hypervalent Iodosulfoximine Reagent

Content Provider	Hyper Articles en Ligne (HAL)
Author	Kalim, Jorna Duhail, Thibaut Pietrasiak, Ewa Anselmi, Elsa Magnier, Emmanuel Togni, Antonio
Abstract	The direct trifluoromethylation of a variety of aliphatic alcohols using a hypervalent iodosulfoximine reagent afforded the corresponding ethers in moderate to good yields (14–72 %). Primary, secondary, and even tertiary alcohols, including examples derived from natural products, underwent this transformation in the presence of catalytic amounts of zinc bis(triflimide). Typical reaction conditions involved a neat mixture of 6.0 equivalents of the alcohol with 1.0 equivalent of the reagent, with the majority of reactions complete within 2 h with 2.5 mol % of the Lewis acid catalyst. Furthermore, experimental evidence was provided that the C−O bond-forming process occurred via the coordination of the alcohol to the iodine atom and subsequent reductive elimination.
Related Links	https://hal.science/hal-03121267/file/Manuscript_chem.202005104.pdf
ISSN	09476539
e-ISSN	15213765
DOI	10.1002/chem.202005104
Journal	Chemistry - A European Journal
Language	English
Publisher	HAL CCSD Wiley-VCH Verlag
Publisher Date	2020-11-26
Access Restriction	Open
Subject Keyword	hypervalent iodine sulfoximines trifluoromethylation organofluorine compounds trifluoromethylethers Chemical Sciences
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis Chemical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in