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Cucurbiturils as potential free radical chemoradiosensitizers for enhanced cisplatin treatment of cancers: a quantum mechanical study
| Content Provider | Hyper Articles en Ligne (HAL) |
|---|---|
| Author | Fong, Clifford W. |
| Copyright Year | 2017 |
| Abstract | It has been shown in this study that the {CisPt@CB[7]} complex can be a source of Pt based free radicals such as (H 3 N) 2 PtCl • and (H 3 N) 2 Pt • • species in water within a radiation environment which can produce hydrated electrons. Encapsulating CisPt within the CB[7] host takes advantage of the previously described drug delivery and reduced side effect advantages of CBs. Based on quantum mechanical modelling and literature results, it is predicted that {CisPt@CB[7]} may interact with cellular macromolecules and engage in an enhanced permeation and retention mechanism in solid tumours, offering further synergistic advantages for a radiation-{CisPt@CB[7]} regimen over that of the conventional radiation-CisPt regimens in current use in anti-cancer chemoradiotherapies. |
| Related Links | https://hal.science/hal-01572258/file/Cucurbiturils%20Radiochemsensitizer1.pdf |
| ISSN | 09230750 |
| e-ISSN | 15731111 |
| DOI | 10.1007/s10847-017-0698-4 |
| Issue Number | 3-4 |
| Volume Number | 87 |
| Journal | Journal of Inclusion Phenomena and Macrocyclic Chemistry |
| Language | English |
| Publisher | HAL CCSD Springer Verlag |
| Publisher Date | 2017-01-01 |
| Access Restriction | Open |
| Subject Keyword | chemoradiotherapy free radicals cucurbit[7]uril cisplatin anti-cancer Medicinal Chemistry Chemical Sciences or physical chemistry Chemical Sciences Theoretical and |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Condensed Matter Physics Food Science |
