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Emergence of cytotoxic resistance in cancer cell populations: single-cell mechanisms and population-level consequences
| Content Provider | Hyper Articles en Ligne (HAL) |
|---|---|
| Author | Lorenzi, Tommaso Chisholm, Rebecca H. Lorz, Alexander Larsen, Annette K Almeida, Luís Escargueil, Alexandre Clairambault, Jean |
| Abstract | We formulate an individual-based model and a population model of phenotypic evolution, under cytotoxic drugs, in a cancer cell population structured by the expression levels of survival-potential and proliferation-potential. We apply these models to a recently studied experimental system. Our results suggest that mechanisms based on fundamental laws of biology can reversibly push an actively-proliferating, and drug-sensitive, cell population to transition into a weakly-proliferative and drug-tolerant state, which will eventually facilitate the emergence of more potent, proliferating and drug-tolerant cells. |
| Related Links | https://inria.hal.science/hal-01249239/file/TL_ICNAAM2015Rhodes.pdf |
| Conference Proceedings | ICNAAM 2015 Session 70: "Mathematical models and methods to investigate heterogeneity in cell and cell population biology" |
| Language | English |
| Publisher | HAL CCSD |
| Publisher Date | 2015-09-27 |
| Access Restriction | Open |
| Subject Keyword | non-genetic instability phenotype evolution Cancer modeling stress-induced adaptation reversible drug tolerance |
| Content Type | Text |
| Resource Type | Conference Proceedings |
| Subject | Mathematics |
