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Enantioselective Insertion of Carbenoids into N-H Bonds Catalyzed by Chiral Bicyclo Bisoxazoline Copper(I) Complexes
| Content Provider | Hyper Articles en Ligne (HAL) |
|---|---|
| Author | Maux, Paul Le Simonneaux, Gérard |
| Abstract | Chiral copper(I)-bicyclobisoxazoline complexes were found to catalyse the insertion of α-diazocarbonyl compounds into N-H bonds of aniline derivatives. The insertion reactions proceeded with high yields (78-99%) and enantioselectivities of up to 81% for the different α-diazopropionates. A predominant effect of the nature and the position of the substituents on the enantiocontrol of the reaction was observed |
| File Format | |
| ISSN | 00404020 |
| DOI | 10.1016/j.tet.2015.10.009 |
| Journal | Tetrahedron |
| Issue Number | 49 |
| Volume Number | 71 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Access Restriction | Open |
| Subject Keyword | Chiral bisoxazoline Copper Enantioselectivity N-H insertion catalysis chim Chemical Sciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Biochemistry |
