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| Content Provider | frontiers |
|---|---|
| Author | Ryan, Michael P. Armshaw, Patricia Pembroke, J. Tony |
| Abstract | Integrative conjugative elements (ICEs) are a class of bacterial mobile elements that have the ability to mediate their own integration, excision, and transfer from one host genome to another by a mechanism of site-specific recombination, self-circularisation, and conjugative transfer. Members of the SXT/R391 ICE family of enterobacterial mobile genetic elements display an unusual UV-inducible sensitization function which results in stress induced killing of bacterial cells harboring the ICE. This sensitization has been shown to be associated with a stress induced overexpression of a mobile element encoded conjugative transfer gene, orf43, a traV homolog. This results in cell lysis and release of a circular form of the ICE. Induction of this novel system may allow transfer of an ICE, enhancing its survival potential under conditions not conducive to conjugative transfer. |
| ISSN | 1664302X |
| DOI | 10.3389/fmicb.2016.00829 |
| Volume Number | 7 |
| Journal | Frontiers in Microbiology |
| Language | English |
| Publisher Date | 2016-05-31 |
| Access Restriction | Open |
| Subject Keyword | UV sensitisation Mobile genetic elements ‘Trap-Door’ escape Integrative conjugative elements (ICEs) Genetic transfer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology Microbiology (medical) |
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