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| Content Provider | frontiers |
|---|---|
| Author | Montero-Vilchez, Trinidad Sierra-Sánchez, Álvaro Sanchez-Diaz, Manuel Quiñones-Vico, Maria Isabel Sanabria-de-la-Torre, Raquel Martinez-Lopez, Antonio Arias-Santiago, Salvador |
| Abstract | The skin is the largest organ of the human body and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing or hair restoration. Mesenchymal stromal cells (MSCs)- conditioned medium (CM) provide a potential opportunity in the treatment of skin disease. Thus, the objective of this review is to evaluate the uses of MSCs-CM for treating skin diseases both in animal and human models. A systematic review was conducted regarding the use of MSCs-CM for treating skin conditions. One hundred and one studies were analysed. MSCs-CM was evaluated in wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15), skin rejuvenation (15) and inflammatory skin diseases (3). MSCs-CM was obtained from different MSC sources, mainly adipose tissue, bone marrow and umbilical cord blood. MSCs-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or intralesional injected or topically applied. MSCs-CM was used in both animals and humans. MSCs-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis and psoriasis both in animals and humans. MSCs-CM also decreased hypertrophic scars and flap ischemia in animal models. In conclusion, MSCs-CM is a promising therapy for skin conditions. Further studies are needed to corroborate safety and effectiveness and to standardize CM manufacturing. |
| ISSN | 2296634X |
| DOI | 10.3389/fcell.2021.654210 |
| Volume Number | 9 |
| Journal | Frontiers in Cell and Developmental Biology |
| Language | English |
| Publisher Date | 2021-07-23 |
| Access Restriction | Open |
| Subject Keyword | Advanced therapy Dermatology Stem Cells Conditioned medium Mesenchymal Stem Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology |
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