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| Content Provider | frontiers |
|---|---|
| Author | Forsell, Mattias N. E. Kvastad, Linda Sedimbi, Saikiran K. Andersson, John Karlsson, Mikael C. I. |
| Abstract | The regulation of germinal center B cell responses to single epitopes is well investigated. How monoclonal B cells are regulated within the polyclonal B cell response to protein antigens is less so. Here, we investigate the primary germinal center B cell response after injection of mice with HIV-1 Envelope glycoproteins. We demonstrate that single germinal centers are seeded by a diverse number of B cell clones shortly after a single immunization and that the presence of Env-specific antibodies can inhibit the development of early germinal center B cells. Importantly, the suppression was dependent on the germinal center B cells and the infused antibodies to target the same subunit of the injected HIV-1 Envelope glycoproteins. An affinity-dependent antibody feedback has previously been shown to regulate germinal center B cell development. Here, we propose that this antibody-based feedback acts on germinal center B cells only if they target the same or overlapping epitopes. This study provides important basic information of germinal center B cell regulation, and for future vaccine designs with aim to elicit neutralizing antibodies against HIV-1. |
| ISSN | 16643224 |
| DOI | 10.3389/fimmu.2017.00738 |
| Volume Number | 8 |
| Journal | Frontiers in Immunology |
| Language | English |
| Publisher Date | 2017-06-30 |
| Access Restriction | Open |
| Subject Keyword | Epitope-specific antibodies Epitope-specific B cells Envelope glycoproteins HIV-1 Regulation of germinal centers |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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