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| Content Provider | frontiers |
|---|---|
| Author | Shahin, Yousef Alabed, Samer Rehan Quadery, Syed Lewis, Robert A. Johns, Christopher Alkhanfar, Dheyaa Sukhanenko, Maria Alandejani, Faisal Garg, Pankaj Elliot, Charlie A. Hameed, Abdul Charalampopoulos, Athaniosis Wild, James M. Condliffe, Robin Swift, Andrew J. Kiely, David G. |
| Abstract | Providing prognostic information is important when counselling patients and planning treatment strategies in chronic thromboembolic pulmonary hypertension (CTEPH). The aim of this study was to assess the prognostic value of gold standard imaging of cardiac structure and function using cardiac magnetic resonance imaging (CMR) in CTEPH. Consecutive treatment-naive patients with CTEPH who underwent right heart catheterization and CMR between 2011 and 2017 were identified from the ASPIRE (Assessing-the-Specturm-of-Pulmonary-hypertensIon-at-a-REferral-centre) registry. CMR metrics were corrected for age and sex where appropriate. Univariate and multivariate regression models were generated to assess the prognostic ability of CMR metrics in CTEPH. 375 patients (mean+/-standard deviation: age 64+/-14 years, 49% female) were identified and 181(48%) had pulmonary endarterectomy (PEA). For all patients with CTEPH, left-ventricular-stroke-volume-index-%predicted (LVSVI%predicted) (p=0.040), left-atrial-volume-index (LAVI) (p=0.030), the presence of comorbidities, incremental shuttle walking test distance (ISWD), mixed venous oxygen saturation and undergoing PEA were independent predictors of mortality at multivariate analysis. In patients undergoing PEA, LAVI (p<0.010), ISWD and comorbidities and in patients not undergoing surgery, right-ventricular-ejection-fraction-%predicted (RVEF%pred) (p=0.040), age and ISWD were independent predictors of mortality. CMR metrics reflecting cardiac function and left heart disease have prognostic value in CTEPH. In those undergoing PEA, LAVI predicts outcome whereas in patients not undergoing PEA RVEF%pred predicts outcome. This study highlights the prognostic value of imaging cardiac structure and function in CTEPH and the importance of considering left heart disease in patients considered for PEA. |
| ISSN | 2296858X |
| DOI | 10.3389/fmed.2022.840196 |
| Volume Number | 9 |
| Journal | Frontiers in Medicine |
| Language | English |
| Publisher Date | 2022-03-14 |
| Access Restriction | Open |
| Subject Keyword | Left atrium Left heart disease Cardiac MRI Chronic thrombembolic pulmonary hypertension Survival |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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