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| Content Provider | frontiers |
|---|---|
| Author | Grogan, Dennis W. |
| Abstract | The Research Topic on mechanisms of preservation and change in archaeal genomes provides a look into current research on how archaea carry out basic genetic processes. Each of the seven contributions (one review and six original research reports) enlarges the basis from which we can better understand the early evolution of cells and develop new methods of archaeal genetics and biotechnology.Topoisomerases, for example, support diverse DNA transactions which determine genome structure and gene expression. Garnier, Couturier, Debat and Nadal provide an informative and authoritative guide to archaeal topoisomerases which they dedicate to the memory of Maria Ciamarella. In addition to explaining these enzymes in mechanistic terms, this review outlines their molecular diversity and biological functions in archaea, including their significance for challenges specific to cells growing under extreme conditions. Homologous recombination is a universal genetic process which supports both the preservation of genome integrity (through repair of double-strand breaks and accurate bypass of unrepaired damage) and genome alteration (through strand or sequence transfer between non-equivalent regions of shared sequence). Wasser, Borst, Hammelmann, Ludt and Soppa used the technique of protoplast fusion to produce artificially heterozygous Haloferax volcanii cells, which allowed recombinants to be recovered without prior genetic selection. Their results indicate that non-reciprocal recombinat... |
| ISSN | 1664302X |
| DOI | 10.3389/fmicb.2021.722509 |
| Volume Number | 12 |
| Journal | Frontiers in Microbiology |
| Language | English |
| Publisher Date | 2021-07-29 |
| Access Restriction | Open |
| Subject Keyword | DNA Primase Archaea Cellular evolution Topoisomerases Biotechnology Genetic Processes Argonaute Proteins DNA polymerases Mismatch repair Endonucleases Extreme conditions Homologous Recombination |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology Microbiology (medical) |
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