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| Content Provider | frontiers |
|---|---|
| Author | Liu, Tianyi Zhou, Linli Li, Danni Andl, Thomas Zhang, Yuhang |
| Abstract | Tumor cells reside in a highly complex and heterogeneous tumor microenvironment (TME), which is composed of a myriad of genetically stable non-cancer cells, including fibroblasts, immune cells, endothelial cells, and epithelial cells, and a tumor-specific extracellular matrix (ECM). Cancer-associated fibroblasts (CAFs), as an abundant and active stromal cell population in the TME, function as the signaling center and remodeling machine to aid the creation of a desmoplastic tumor niche. Although there is no denial that the TME and CAFs may have anti-tumor effects as well, a great deal of findings reported in recent years have convincingly revealed the tumor-promoting effects of CAFs and CAF-derived ECM proteins, enzymes, chemical factors and other downstream effectors. While there is growing enthusiasm for the development of CAF-targeting therapies, a better understanding of the complexities of CAF-ECM and CAF-cancer cell interactions is necessary before novel therapeutic strategies targeting the malignant tumor “soil” can be successfully implemented in the clinic. |
| ISSN | 2296634X |
| DOI | 10.3389/fcell.2019.00060 |
| Volume Number | 7 |
| Journal | Frontiers in Cell and Developmental Biology |
| Language | English |
| Publisher Date | 2019-04-24 |
| Access Restriction | Open |
| Subject Keyword | Cancer-associated fibroblast Tumor Microenvironment Therapy Extracellular Matrix Mechanoreciprocity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology |
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