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| Content Provider | frontiers |
|---|---|
| Author | Scala, Emanuele Zink, Alexander |
| Abstract | Hidradenitis suppurativa (HS) is a chronic, debilitating, inflammatory disease of the pilosebaceous unit characterized by painful nodules, abscesses, sinus tracts, and scar formation, affecting ~1% of the general population with common onset in young adulthood (1). HS is clinically under-recognized, and the diagnosis takes, in median, 7 years to be made (2). It has an extremely high comorbidity burden, rate of hospitalization, and recalcitrance to treatment deeply affecting patients' quality of life (1,2). To date, the pathogenesis of HS is only partially understood and the lack of knowledge regarding the intersection of genetics, immunology and environmental risk factors (e.g., smoking, obesity, and mechanical friction) is a major obstacle to improving treatment for patients with HS (1)(2)(3)(4).In this research topic, we invited scientists to summarize the latest updates on HS pathogenesis, diagnosis, and treatments.The topic started with a non-interventional, cross sectional monocentric study by Sabat el al. revealing a number of sex-related differences for disease risk factors, clinical aspects, and comorbidity in 500 patients suffering from HS (303 women and 197 men). Central obesity was more frequent in women while extensive cigarette smoking and acne vulgaris were more commonly found among male patients. The latter reported more often lower blood HDLcholesterol levels, higher blood glucose levels, and experienced arterial hypertension than HS afflicted women. Clinic... |
| ISSN | 2296858X |
| DOI | 10.3389/fmed.2023.1209545 |
| Volume Number | 10 |
| Journal | Frontiers in Medicine |
| Language | English |
| Publisher Date | 2023-05-10 |
| Access Restriction | Open |
| Subject Keyword | Treatment Hidradenitis Suppurativa Acne inversa Pathogenesis Diagnosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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