NDLI: A review for discovering bioactive minor saponins and biotransformative metabolites in Panax quinquefolius L.

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Bu-Gu-Sheng-Sui decoction promotes osteogenesis via activating the ERK/Smad signaling pathways

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Creatinine accelerates APAP-induced liver damage by increasing oxidative stress through ROS/JNK signaling pathway

Structural features and antioxidant activities of polysaccharides from different parts of Codonopsis pilosula var. modesta (Nannf.) L. T. Shen

Potential drug-drug interactions in drug therapy for older adults with chronic coronary syndrome at hospital discharge: A real-world study

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The efficacy and safety of JAK inhibitors for alopecia areata: A systematic review and meta-analysis of prospective studies

Oroxylin A ameliorates AKI-to-CKD transition through maintaining PPARα-BNIP3 signaling-mediated mitochondrial homeostasis

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The Application of Pearls in Traditional Medicine of China and Their Chemical Constituents, Pharmacology, Toxicology, and Clinical Research

Anti-inflammatory activities of Qingfei oral liquid and its influence on respiratory microbiota in mice with ovalbumin-induced asthma

The add-on effects of Danhong injection among patients with ischemic stroke receiving Western medicines: A systematic review and meta-analysis

Generalised weibull model-based approaches to detect non-constant hazard to signal adverse drug reactions in longitudinal data

Experimental treatments to attenuate blood spinal cord barrier rupture in rats with traumatic spinal cord injury: A meta-analysis and systematic review

Traditional Chinese medicine: An important source for discovering candidate agents against hepatic fibrosis

Paeoniflorin alleviates liver injury in hypercholesterolemic rats through the ROCK/AMPK pathway

Therapeutic insights elaborating the potential of retinoids in Alzheimer’s disease

BioSAXS–an emerging method to accelerate, enrich and de-risk antimicrobial drug development

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Review of Urate-Lowering Therapeutics: From the Past to the Future

Renovation as innovation: Repurposing human antibacterial peptide LL-37 for cancer therapy

Dex modulates the balance of water-electrolyte metabolism by depressing the expression of AVP in PVN

Blood vessel assessment using computed tomography : Effects of ephedrine on uterine artery

A bibliometric analysis of the 100 most-cited articles on curcumin

CB2 cannabinoid receptor expression is increased in 129S1/SvImJ mice: behavioral consequences

The change of drug utilization in China’s public healthcare institutions under the “4 + 7” centralized drug procurement policy: Evidence from a natural experiment in China

Bibliometric study of soluble guanylate cyclase stimulators in cardiovascular research based on web of science from 1992 to 2021

A randomized, double-blind, parallel control study to evaluate the biosimilarity of QL1209 with Perjeta® in healthy male subjects

Bibliometric and visual analysis of blood-testis barrier research

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Qingfei Jiedu decoction inhibits PD-L1 expression in lung adenocarcinoma based on network pharmacology analysis, molecular docking and experimental verification

Dose-dependent reduction of lymphocyte count and heart rate after multiple administration of LC51-0255, a novel sphingosine-1-phosphate receptor 1 modulator, in healthy subjects

Identification and validation of key biomarkers for the early diagnosis of diabetic kidney disease

Editorial: Ion channels and transporters in diabetes and metabolic diseases

Meta-analysis and trial sequential analysis of shexiang baoxin pill for coronary slow flow

Current situation and future development of the biopharmaceutical industry in China: A mixed-method study

Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential

Influence of the gut microbiota on endometriosis: Potential role of chenodeoxycholic acid and its derivatives

Flavonol glycoside complanatoside A requires FOXO/DAF-16, NRF2/SKN-1, and HSF-1 to improve stress resistances and extend the life span of Caenorhabditis elegans

Physicians’ Knowledge, Altitudes, and Perceived Barriers of Inappropriate Prescribing for Older Patients in Shanghai, China

Danhong injection attenuates doxorubicin-induced cardiotoxicity in rats via suppression of apoptosis: network pharmacology analysis and experimental validation

Huangkui lianchang decoction attenuates experimental colitis by inhibiting the NF-κB pathway and autophagy

Structural modification of octadecanoic acid-3,4-tetrahydrofuran diester and the acaricidal activity and mechanism of its derivatives against Sarcoptesscabiei var. Cuniculi

Risk assessment and molecular mechanism study of drug-drug interactions between rivaroxaban and tyrosine kinase inhibitors mediated by CYP2J2/3A4 and BCRP/P-gp

Link of sorafenib resistance with the tumor microenvironment in hepatocellular carcinoma: Mechanistic insights

Cardiovascular outcomes of metformin use in patients with type 2 diabetes and chronic obstructive pulmonary disease

Effect of ranibizumab on retinopathy of prematurity: A meta-analysis

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The role of resveratrol on rheumatoid arthritis: From bench to bedside

Metabolomics profiling reveals berberine-inhibited inflammatory response in human gingival fibroblasts by regulating the LPS-induced apoptosis signaling pathway

Total flavonoids of hawthorn leaves protect spinal motor neurons via promotion of autophagy after spinal cord injury

Clinical efficacy, safety, and cost of nine Chinese patent medicines combined with ACEI/ARB in the treatment of early diabetic kidney disease: A network meta-analysis

Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-XL ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy

Nalidixic acid potentiates the antitumor activity in sorafenib-resistant hepatocellular carcinoma via the tumor immune microenvironment analysis

Atezolizumab plus platinum-based chemotherapy as first-line therapy for metastatic urothelial cancer: A cost-effectiveness analysis

Penilloic acid is the chief culprit involved in non-IgE mediated, immediate penicillin-induced hypersensitivity reactions in mice

Cell-cycle and apoptosis related and proteomics-based signaling pathways of human hepatoma Huh-7 cells treated by three currently used multi-RTK inhibitors

Efficacy of immune checkpoint inhibitors in EGFR-Mutant NSCLC patients with EGFR-TKI resistance: A systematic review and meta-analysis

Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing

Adverse drug reactions and correlations with drug–drug interactions: A retrospective study of reports from 2011 to 2020

Cysteamine affects skeletal development and impairs motor behavior in zebrafish

A comprehensive review on disposition kinetics and dosage of oral administration of Andrographis paniculata, an alternative herbal medicine, in co-treatment of coronavirus disease

Targeted bile acid profiles reveal the liver injury amelioration of Da-Chai-Hu decoction against ANIT- and BDL-induced cholestasis

Drug-loaded PEG-PLGA nanoparticles for cancer treatment

Bidirectional regulatory effects of Cordyceps on arrhythmia: Clinical evaluations and network pharmacology

The evaluation of ADME and pharmacokinetic properties of decoquinate derivatives for the treatment of malaria

Bioactive natural products in COVID-19 therapy

Using network pharmacology to explore the mechanism of Danggui-Shaoyao-San in the treatment of diabetic kidney disease

Qu-Du-San-Jie decoction induces growth inhibition and vascular normalization in NF2-associated vestibular schwannoma

Postponement of the opacification of lentoid bodies derived from human induced pluripotent stem cells after lanosterol treatment—the first use of the lens aging model in vitro in cataract drug screening

Acteoside attenuates RSV-induced lung injury by suppressing necroptosis and regulating metabolism

The phytochemical properties, pharmacological effects and traditional uses of Actinidia eriantha Benth.: A review

Potential therapeutic applications of infusions and hydroalcoholic extracts of Romanian glutinous sage (Salvia glutinosa L.)

Identification of endoplasmic reticulum stress-associated genes and subtypes for prediction of Alzheimer’s disease based on interpretable machine learning

The expression and significance of efferocytosis and immune checkpoint related molecules in pancancer samples and the correlation of their expression with anticancer drug sensitivity

A single-dose, randomized, open-labeled, parallel-group study comparing the pharmacokinetics, pharmacodynamics and safety of leuprolide acetate microspheres 3.75 mg and Enantone® 3.75 mg in healthy male subjects

Potential therapeutics against neurological disorders: Natural products-based drugs

Anti-tumour necrosis factor-alpha agent therapy, compared with conventional therapy, reduces the relapse of uveitis in patients with behçet’s disease: A systematic review of controlled trials

Baoyuan Jiedu decoction alleviating cancer cachexia–Induced muscle atrophy by regulating muscle mitochondrial function in ApcMin/+ mice

Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice

The combination of Lonicerae Japonicae Flos and Forsythiae Fructus herb-pair alleviated inflammation in liver fibrosis

Ruxolitinib inhibits cytokine production by human lung macrophages without impairing phagocytic ability

Identification of a potent NAFLD drug candidate for controlling T2DM-mediated inflammation and secondary damage in vitro and in vivo

Metabolomics profiles in acute-on-chronic liver failure: Unveiling pathogenesis and predicting progression

Editorial: Venoms, animal and microbial toxins, volume II

Acacia sieberiana (Fabaceae) attenuates paracetamol and Bile Duct Ligation-Induced hepatotoxicity via modulation of biochemical and oxidative stress biomarkers

Astragaloside IV attenuates ferroptosis after subarachnoid hemorrhage via Nrf2/HO-1 signaling pathway

Apolipoprotein A-I mimetic peptides (ApoAI MP) improve oxidative stress and inflammatory responses in Parkinson’s disease mice

Genome-wide association analysis of anti-TNF-α treatment response in Chinese patients with psoriasis

Evaluation of in vivo antibacterial drug efficacy using Caenorhabditiselegans infected with carbapenem-resistant Klebsiella pneumoniae as a model host

Dexmedetomidine alleviates olfactory cognitive dysfunction by promoting neurogenesis in the subventricular zone of hypoxic-ischemic neonatal rats

Therapeutic targets by traditional Chinese medicine for ischemia-reperfusion injury induced apoptosis on cardiovascular and cerebrovascular diseases

Therapeutic potential and molecular mechanisms of salidroside in ischemic diseases

Kill two birds with one stone: Engineered exosome-mediated delivery of cholesterol modified YY1-siRNA enhances chemoradiotherapy sensitivity of glioblastoma

Editorial: Emerging and old viral diseases: Antiviral drug discovery from medicinal plants

A ubiquitin-related gene signature for predicting prognosis and constructing molecular subtypes in osteosarcoma

Investigation into the in vivo mechanism of diosmetin in patients with breast cancer and COVID-19 using bioinformatics

Case Report: A good response to furmonertinib second-line treatment of an advanced lung adenocarcinoma patient with a rare EGFR exon 20 N771_P772insH mutation: A case report and literature review

Flos puerariae ameliorates the intestinal inflammation of Drosophila via modulating the Nrf2/Keap1, JAK-STAT and Wnt signaling

Prophylactic administration of tranexamic acid combined with thromboelastography-guided hemostatic algorithm reduces allogeneic transfusion requirements during pediatric resective epilepsy surgery: A randomized controlled trial

Editorial: Nanomedicine in Infectious Diseases: Drug Delivery and Vaccines

Impact of extracorporeal membrane oxygenation on voriconazole plasma concentrations: A retrospective study

Formation of pre-metastatic bone niche in prostate cancer and regulation of traditional chinese medicine

Adding Chinese Herbal Medicine to Routine Care is Associated With a Lower Risk of Rheumatoid Arthritis Among Patients With Asthma: A Population-Based Retrospective Cohort Study

Evaluating the therapeutic role of selected active compounds in Plumula Nelumbinis on pulmonary hypertension via network pharmacology and experimental analysis

Case report: Kinetics of human leukocyte antigen receptor HLA-DR during liver injury induced by potassium para-aminobenzoate as assessed for causality using the updated RUCAM

The roles of glycolysis in osteosarcoma

Molecular mechanisms of programmed cell death in methamphetamine-induced neuronal damage

Integrated bioinformatics analysis uncovers characteristic genes and molecular subtyping system for endometriosis

Changes in serum metabolomics in idiopathic pulmonary fibrosis and effect of approved antifibrotic medication

The median effective analgesic concentration of ropivacaine in ultrasound-guided interscalene brachial plexus block after arthroscopic rotator cuff repair

New strategies for identifying and masking the bitter taste in traditional herbal medicines: The example of Huanglian Jiedu Decoction

Activin receptor-like kinase 7 promotes apoptosis of vascular smooth muscle cells via activating Smad2/3 signaling in diabetic atherosclerosis

Pharmacological investigation of brucine anti-ulcer potential

Therapeutic effects of shaogan fuzi decoction in rheumatoid arthritis: Network pharmacology and experimental validation

Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy

Retinal microglia protect against vascular damage in a mouse model of retinopathy of prematurity

Shenkang injection improves chronic kidney disease by inhibiting multiple renin-angiotensin system genes by blocking the Wnt/β-catenin signalling pathway

Exploring the pathogenesis of diabetic kidney disease by microarray data analysis

Characterization of Nasco grape pomace-loaded nutriosomes and their neuroprotective effects in the MPTP mouse model of Parkinson’s disease

Apatinib for recurrent/progressive glioblastoma multiforme: A salvage option

The impacts of the “4+7” pilot policy on the volume, expenditures, and daily cost of Serotonin-Specific Reuptake Inhibitors (SSRIs) antidepressants: A quasi-experimental study

Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?

Effects of propofol on macrophage activation and function in diseases

Temozolomide hexadecyl ester targeted plga nanoparticles for drug-resistant glioblastoma therapy via intranasal administration

The inhibitory effect of some pyrazole ligands and their Cu(II) complexes on the growth of Escherichia coli, Klebsiella–Enterobacter spp., and Staphylococcus aureus

Anti-NMDA receptor encephalitis and vaccination: A disproportionality analysis

Simultaneous absolute protein quantification of seven cytochrome P450 isoforms in rat liver microsomes by LC-MS/MS-based isotope internal standard method

Astragalus Polysaccharides Alleviate Type 2 Diabetic Rats by Reversing the Expressions of Sweet Taste Receptors and Genes Related to Glycolipid Metabolism in Liver

The comparative effects of oral Chinese patent medicines combined with western medicine in stable angina: A systematic review and network meta-analysis of 179 trials

Genome-wide microRNA profiles identify miR-107 as a top miRNA associating with expression of the CYP3As and other drug metabolizing cytochrome P450 enzymes in the liver

Enhanced liver fibrosis score as a noninvasive biomarker in hepatitis C virus patients after direct-acting antiviral agents

Network pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19

Multimodal neuroimage data fusion based on multikernel learning in personalized medicine

Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages

Protective effect of quercetin on cadmium-induced renal apoptosis through cyt-c/caspase-9/caspase-3 signaling pathway

Effect of indobufen vs. aspirin on platelet accumulation in patients with stable coronary heart disease after percutaneous coronary intervention: An open-label crossover study

Real-world association of adherence with outcomes and economic burden in patients with tuberculosis from South Korea claims data

Succinum extracts inhibit microglial-derived neuroinflammation and depressive-like behaviors

Effects of 3,4-diaminopyridine on myasthenia gravis: Preliminary results of an open-label study

Steviol glycosides as an alternative osmotic agent for peritoneal dialysis fluid

Corrigendum: Clinical efficacy protocol of yinhuapinggan granules: A randomized, double-blind, parallel, and controlled clinical trial program for the intervention of community-acquired drug-resistant bacterial pneumonia as a complementary therapy

Physiologically based pharmacokinetic modeling of daptomycin dose optimization in pediatric patients with renal impairment

Solanum nigrum Linn.: An Insight into Current Research on Traditional Uses, Phytochemistry, and Pharmacology

Effect of Rumex dentatus on Gastrointestinal Protection and Toxicology in Rodents via Investigating H+/K+-ATPase, Calcium Channels, and PDE Mediated Signaling

Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and fibrosis via the NF-κB signaling pathway

Effectiveness and safety analysis of SanHanHuaShi granules for the treatment of coronavirus disease 2019: Study protocol and statistical analysis plan for a randomized, parallel-controlled, open-label clinical trial

Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, a Potential Oral Drug Candidate for COVID-19 Treatment

Photodynamic therapy in pediatric age: Current applications and future trends

Total extract of Abelmoschus manihot L. alleviates uric acid-induced renal tubular epithelial injury via inhibition of caspase-8/caspase-3/NLRP3/GSDME signaling

Hyperstable EGF-like bleogen derived from cactus accelerates corneal healing in rats

Editorial: Vascular smooth muscle cell fate and vascular remodeling: Mechanisms, therapeutic targets, and drugs, volume I

Editorial: Clinical safety of natural products, an evidence-based approach

Modern drug self-medication and associated factors among pregnant women at Settat city, Morocco

Anti-PD-L1 immunoconjugates for cancer therapy: Are available antibodies good carriers for toxic payload delivering?

Combined targeting of pathways regulating synaptic formation and autophagy attenuates Alzheimer’s disease pathology in mice

Transjugular intrahepatic portosystemic shunt for the prevention of rebleeding in patients with cirrhosis and portal vein thrombosis: Systematic review and meta-analysis

Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo

Alleviating insomnia should decrease the risk of irritable bowel syndrome: Evidence from Mendelian randomization

Comprehensive bibliometric analysis of sirtuins: Focus on sirt1 and kidney disease

Progress on structural modification of Tetrandrine with wide range of pharmacological activities

Combining fecal microbiome and metabolomics to reveal the disturbance of gut microbiota in liver injury and the therapeutic mechanism of shaoyao gancao decoction

Real-world effectiveness of Yindan Jiedu granules-based treatment on patients infected with the SARS-CoV-2 Omicron variants BA.2 combined with high-risk factors: A cohort study

Morinda officinalis oligosaccharides mitigate chronic mild stress-induced inflammation and depression-like behaviour by deactivating the MyD88/PI3K pathway via E2F2

Z1456467176 alleviates gouty arthritis by allosterically modulating P2X7R to inhibit NLRP3 inflammasome activation

Population pharmacokinetic/pharmacodynamic analysis of AK111, an IL-17A monoclonal antibody, in subjects with moderate-to-severe plaque psoriasis

Characterization of the SGLT2 Interaction Network and Its Regulation by SGLT2 Inhibitors: A Bioinformatic Analysis

The crosstalk between sonodynamic therapy and autophagy in cancer

Smart therapies against global pandemics: A potential of short peptides

Metformin anticancer: Reverses tumor hypoxia induced by bevacizumab and reduces the expression of cancer stem cell markers CD44/CD117 in human ovarian cancer SKOV3 cells

New insights into natural products that target the gut microbiota: Effects on the prevention and treatment of colorectal cancer

A review for the pharmacological effects of paeoniflorin in the nervous system

Role of ferroptosis and ferroptosis-related non-coding RNAs in the occurrence and development of gastric cancer

Time to First Line Antiretroviral Therapy Adverse Drug Reaction and its Predictors Among Adult HIV/AIDS Patients on Treatment in Eastern Ethiopia

The Role and Therapeutic Potential of Macropinocytosis in Cancer

Editorial: New trends in natural product research for inflammatory and infectious diseases

Astragalus mongholicus powder, a traditional Chinese medicine formula ameliorate type 2 diabetes by regulating adipoinsular axis in diabetic mice

Pinelliae rhizoma alleviated acute lung injury induced by lipopolysaccharide via suppressing endoplasmic reticulum stress-mediated NLRP3 inflammasome

Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice

Pan-cancer analysis suggests histocompatibility minor 13 is an unfavorable prognostic biomarker promoting cell proliferation, migration, and invasion in hepatocellular carcinoma

Effect of troxerutin in counteracting hyperglycemia-induced VEGF upregulation in endothelial cells: a new option to target early stages of diabetic retinopathy?

Editorial: Leveraging pharmacovigilance data mining with “the patient” in mind

Authorization of COVID-19 clinical trials: lessons from 2 years of experience of a national competent authority

A synthetic BBB-permeable tripeptide GCF confers neuroprotection by increasing glycine in the ischemic brain

Corrigendum: Polysaccharides of Dendrobium officinale Kimura & Migo leaves protect against ethanol-induced gastric mucosal injury via the AMPK/mTOR signaling pathway in vitro and vivo

Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases

Nonerythropoietic Erythropoietin Mimetic Peptide ARA290 Ameliorates Chronic Stress-Induced Depression-Like Behavior and Inflammation in Mice

The Anticancer Effects of the Pro-Apoptotic Benzofuran-Isatin Conjugate (5a) Are Associated With p53 Upregulation and Enhancement of Conventional Chemotherapeutic Drug Efficiency in Colorectal Cancer Cell Lines

Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2

Taohong siwu decoction attenuates AIM2 and NLRC4 inflammasomes by ameliorates deoxyribonucleic acid damage after ischemic stroke

Design, synthesis, and biological characterization of a potent STAT3 degrader for the treatment of gastric cancer

Integrating network pharmacology analysis and pharmacodynamic evaluation for exploring the active components and molecular mechanism of moutan seed coat extract to improve cognitive impairment

Investigation of the mechanism of the anti-cancer effects of Astragalus propinquus Schischkin and Pinellia pedatisecta Schott (A&P) on melanoma via network pharmacology and experimental verification

Hesperidin promotes gastric motility in rats with functional dyspepsia by regulating Drp1-mediated ICC mitophagy

Rosmarinus officinalis and Methylphenidate Exposure Improves Cognition and Depression and Regulates Anxiety-Like Behavior in AlCl3-Induced Mouse Model of Alzheimer’s Disease

Better detoxifying effect of ripe forsythiae fructus over green forsythiae fructus and the potential mechanisms involving bile acids metabolism and gut microbiota

Kanglaite (Coix Seed Extract) as Adjunctive Therapy in Cancer: Evidence Mapping Overview Based on Systematic Reviews With Meta-Analyses

Efficacy and mechanism of Jiedu Tongluo Tiaogan Formula in treating type 2 diabetes mellitus combined with non-alcoholic fatty liver disease: Study protocol for a parallel-armed, randomized controlled trial

Case Report: Fluzoparib for multiple lines of chemotherapy refractory in metastatic cutaneous squamous cell carcinoma with BRCA2 pathogenic mutation

Preclinical safety evaluation of Macleaya Cordata extract: A re-assessment of general toxicity and genotoxicity properties in rodents

Research progress and applications of nanobody in human infectious diseases

Norcantharidin overcomes vemurafenib resistance in melanoma by inhibiting pentose phosphate pathway and lipogenesis via downregulating the mTOR pathway

Ninjinyoeito improves social behavior disorder in neuropeptide Y deficient zebrafish

Up-and-coming anti-epileptic effect of aloesone in Aloe vera: Evidenced by integrating network pharmacological analysis, in vitro, and in vivo models

Edaravone use in acute intracerebral hemorrhage: A systematic review and meta-analysis of randomized controlled trials

Cost-effectiveness analysis of olaparib as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation in china

Alterations in sorting and secretion of hepatic apoA5 induce hypertriglyceridemia due to short-term use of olanzapine

Differentiating central nervous system demyelinating disorders: The role of clinical, laboratory, imaging characteristics and peripheral blood type I interferon activity

TMAO as a potential biomarker and therapeutic target for chronic kidney disease: A review

Exogenous Urokinase Inhibits Proteasomal Degradation of Its Cognate Urokinase Plasminogen Activator Receptor

Inhibitory effect of (pro)renin receptor decoy inhibitor PRO20 on endoplasmic reticulum stress during cardiac remodeling

Corrigendum: Assessment of the anti-inflammatory, antibacterial and anti-aging properties and possible use on the skin of hydrogels containing Epilobium angustifolium L. extracts

Anxiolytic-like effects of hochuekkito in lipopolysaccharide-treated mice involve interleukin-6 inhibition

Corrigendum: TEOA inhibits proliferation and induces DNA damage of diffuse large B-cell lymphoma cells through activation of the ROS-dependent p38 MAPK signaling pathway

Integrate thermostabilized fusion protein apocytochrome b562RIL and N-glycosylation mutations: A novel approach to heterologous expression of human UDP-glucuronosyltransferase (UGT) 2B7

A compatibility evaluation between the physiologically based pharmacokinetic (PBPK) model and the compartmental PK model using the lumping method with real cases

Editorial: Kappa opioid receptors revealed: Disentangling the pharmacology to open up new therapeutic strategies

Biomarker panel for early screening of trastuzumab -induced cardiotoxicity among breast cancer patients in west virginia

Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population

Distinct alterations of fecal microbiota refer to the efficacy of adalimumab in Crohn’s disease

Kuoxin Decoction promotes lymphangiogenesis in zebrafish and in vitro based on network analysis

Melatonin promotes sirtuin 1 expression and inhibits IRE1α–XBP1S–CHOP to reduce endoplasmic reticulum stress–mediated apoptosis in chondrocytes

Chaperone activity of niflumic acid on ClC-1 chloride channel mutants causing myotonia congenita

Reimbursed medication adherence enhancing interventions in 12 european countries: Current state of the art and future challenges

Analgesic Action of Catechin on Chronic Constriction Injury–Induced Neuropathic Pain in Sprague–Dawley Rats

Curcuma longa and Boswellia serrata Extracts Modulate Different and Complementary Pathways on Human Chondrocytes In Vitro: Deciphering of a Transcriptomic Study

Significant metabolic alterations in non-small cell lung cancer patients by epidermal growth factor receptor-targeted therapy and PD-1/PD-L1 immunotherapy

Phaseolus vulgaris extract ameliorates high-fat diet-induced colonic barrier dysfunction and inflammation in mice by regulating peroxisome proliferator-activated receptor expression and butyrate levels

Enhanced healing of oral chemical burn by inhibiting inflammatory factors with an oral administration of shengFu oil

Inhibiting Cytoprotective Autophagy in Cancer Therapy: An Update on Pharmacological Small-Molecule Compounds

Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells

Editorial: Biomedical advances in ultrasound-mediated drug/molecule delivery

Crocin-I Protects Against High-Fat Diet-Induced Obesity via Modulation of Gut Microbiota and Intestinal Inflammation in Mice

Bipartite graph search optimization for type II diabetes mellitus Jamu formulation using branch and bound algorithm

Investigating the effects of Liushen Capsules (LS) on the metabolome of seasonal influenza: A randomized clinical trial

Astragaloside IV promotes pharmacological effect of Descurainia sophia seeds on isoproterenol-induced cardiomyopathy in rats by synergistically modulating the myosin motor

Dihydroartemisinin remodels macrophage into an M1 phenotype via ferroptosis-mediated DNA damage

Case Report: Clinical complete response of advanced renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion by treated by camrelizumab and axitinib: A rare case report

Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line

Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo

Oxaliplatin Eluting CalliSpheres Microspheres for the Treatment of Unresectable or Recurrent Hepatocellular Carcinoma

Engaging plasticity: Differentiation therapy in solid tumors

Short-term efficacy and safety of a lower dose of polyethylene glycol recombinant human growth hormone in children with growth hormone deficiency: A randomized, dose-comparison study

Exploration of beta-arrestin isoform signaling pathways in delta opioid receptor agonist-induced convulsions

Synthetic short-chain peptide analogues of H1 relaxin lack affinity for the RXFP1 receptor and relaxin-like bioactivity. Clues to a better understanding of relaxin agonist design

Editorial: Eicosanoids and cytokines: Resolution of inflammation

Corrigendum: Myelodysplastic syndrome/acute myeloid leukemia following the use of poly-ADP ribose polymerase inhibitors: A real-world analysis of postmarketing surveillance data

Real-world effectiveness of biological therapy in patients with rheumatoid arthritis: Systematic review and meta-analysis

Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9

Corrigendum: Total flavonoids of Rhizoma Drynariae ameliorate bone growth in experimentally induced tibial dyschondroplasia in chickens via regulation of OPG/RANKL axis

Editorial: Natural compounds as scaffolds for the discovery of new anti-cancer drugs: Focus on terpenoids and flavonoids

Development and validation of a UPLC-MS/MS method with volumetric absorptive microsampling to quantitate cyclophosphamide and 4-hydroxycyclophosphamide

Efficacy and Safety of Apatinib for the Treatment of Advanced or Recurrent Cervical Cancer: A Single-Arm Meta-Analysis Among Chinese Patients

A machine learning-based risk warning platform for potentially inappropriate prescriptions for elderly patients with cardiovascular disease

Posaconazole inhibits the stemness of cancer stem-like cells by inducing autophagy and suppressing the Wnt/β-catenin/survivin signaling pathway in glioblastoma

Herbal medicine used in the treatment of cardiovascular diseases in the Rif, North of Morocco

Roles of exosomes and exosome-derived miRNAs in pulmonary fibrosis

An integrative approach to uncover the components, mechanisms, and functions of traditional Chinese medicine prescriptions on male infertility

Leveraging Predictive Pharmacometrics-Based Algorithms to Enhance Perinatal Care—Application to Neonatal Jaundice

Artemisinin relieves myocardial ischemia-reperfusion injury via modulating miR-29b-3p and hemicentin 1

Lower risk of ischemic stroke among patients with chronic kidney disease using chinese herbal medicine as add-on therapy: A real-world nationwide cohort study

Safety of biological therapy in patients with rheumatoid arthritis in administrative health databases: A systematic review and meta-analysis

Taccalonolides: Structure, semi-synthesis, and biological activity

Inhibiting vascular smooth muscle cell proliferation mediated by osteopontin via regulating gut microbial lipopolysaccharide: A novel mechanism for paeonol in atherosclerosis treatment

A combined aging and immune prognostic signature predict prognosis and responsiveness to immunotherapy in melanoma

Licensing of Orphan Medicinal Products—Use of Real-World Data and Other External Data on Efficacy Aspects in Marketing Authorization Applications Concluded at the European Medicines Agency Between 2019 and 2021

Antioxidant and Anti-Inflammatory Properties of Hydroxyl Safflower Yellow a in Diabetic Nephropathy: A Meta-Analysis of Randomized Controlled Trials

Pan-cancer analyses identify DCBLD2 as an oncogenic, immunological, and prognostic biomarker

Molecular mechanisms and physiological functions of autophagy in kidney diseases

Potential protective benefits of Schisandrin B against severe acute hepatitis in children during the COVID-19 pandemic based on a network pharmacology analysis

Identification of the key ferroptosis-related genes involved in sepsis progression and experimental validation in vivo

National trends in the use of oral chemotherapy over 13 years

Identification of solamargine as a cisplatin sensitizer through phenotypical screening in cisplatin-resistant NSCLC organoids

The role of NPC1L1 in cancer

Analysis of regulating activities of 5′-epiequisetin on proliferation, apoptosis, and migration of prostate cancer cells in vitro and in vivo

Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review

Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms

The pyroptosis-related gene signature predicts prognosis and reveals characterization of the tumor immune microenvironment in acute myeloid leukemia

β-elemene Isopropanolamine Derivative LXX-8250 Induces Apoptosis Through Impairing Autophagic Flux via PFKFB4 Repression in Melanoma Cells

Case report: Long-term partial response of apatinib plus paclitaxel as second-line therapy in a patient with metastatic gastric cancer

Unbiased transcriptome mapping and modeling identify candidate genes and compounds of osteoarthritis

Design, synthesis and biological evaluation of erlotinib-based IDO1 inhibitors

Efficacy and safety of combined immunotherapy and antiangiogenesis with or without chemotherapy for advanced non-small-cell lung cancer: A systematic review and pooled analysis from 23 prospective studies

Distribution and metabolism of daidzein and its benzene sulfonates in vivo (in mice) based on MALDI-TOF MSI

N-Acetylcysteine for Preventing Acetaminophen-Induced Liver Injury: A Comprehensive Review

Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review

Comparison on different traditional Chinese medicine therapies for chronic hepatitis B liver fibrosis

Osimertinib: Another medication related to osteonecrosis of the jaws? A case report and literature review

Renshen Baidu powder protects ulcerative colitis via inhibiting the PI3K/Akt/NF-κB signaling pathway

Clinical Efficacy and In Vitro Drug Sensitivity Test Results of Azithromycin Combined With Other Antimicrobial Therapies in the Treatment of MDR P. aeruginosa Ventilator-Associated Pneumonia

Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies

Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics

Effects of GLP-1 Receptor Agonists on Biological Behavior of Colorectal Cancer Cells by Regulating PI3K/AKT/mTOR Signaling Pathway

Chinese herbal medicine xuebijing injection for acute pancreatitis: An overview of systematic reviews

Antiosteoporosis effect of tanshinol in osteoporosis animal models: A systematic review and meta-analysis

The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies

Celastrol ameliorates osteoarthritis via regulating TLR2/NF-κB signaling pathway

Therapeutic mechanism of Curcuma aromatica Salisb. rhizome against coronary heart disease based on integrated network pharmacology, pharmacological evaluation and lipidomics

Raman and fluorescence micro-spectroscopy applied for the monitoring of sunitinib-loaded porous silicon nanocontainers in cardiac cells

Drug-drug interactions between antithrombotics and direct-acting antivirals in hepatitis C virus (HCV) patients: A brief, updated report

LC–MS-based lipidomic analysis of liver tissue sample from spontaneously hypertensive rats treated with extract hawthorn fruits

Identification of PARP12 Inhibitors By Virtual Screening and Molecular Dynamics Simulations

Structure and Mechanism of Glycine Receptor Elucidated by Cryo-Electron Microscopy

In vitro assessment of the probiotic properties of an industrial preparation containing Lacticaseibacillus paracasei in the context of athlete health

Cratoxylumxanthone C, a natural xanthone, inhibits lung cancer proliferation and metastasis by regulating STAT3 and FAK signal pathways

Structures of the SARS-CoV-2 spike glycoprotein and applications for novel drug development

Diabetic retinopathy: Involved cells, biomarkers, and treatments

Lipid-based nanoparticles and RNA as innovative neuro-therapeutics

Plant-derived bioactive compounds regulate the NLRP3 inflammasome to treat NAFLD

Eugenol: A novel therapeutic agent for the inhibition of Candida species infection

2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer’s therapy: In vitro, kinetic, in silico, and in vivo potentials

A novel necroptosis-related LncRNA signature for prediction of prognosis and therapeutic responses of head and neck squamous cell carcinoma

Traditional Chinese herbs and natural products in hyperuricemia-induced chronic kidney disease

Identification of molecular patterns and prognostic models of epithelial–mesenchymal transition- and immune-combined index in the gastric cancer

In silico analysis and preclinical findings uncover potential targets of anti-cervical carcinoma and COVID-19 in laminarin, a promising nutraceutical

Neuronal MD2 induces long-term mental impairments in septic mice by facilitating necroptosis and apoptosis

New insight into ischemic stroke: Circadian rhythm in post-stroke angiogenesis

Editorial: Cytokine Release Syndrome in COVID-19: Mechanisms and Management

Structural modifications of berberine and their binding effects towards polymorphic deoxyribonucleic acid structures: A review

Spectrum effect correlation of yangyin tongnao granules on cerebral ischemia-reperfusion injury rats

Corrigendum: Integrated chemical interpretation and network pharmacology analysis to reveal the anti-liver fibrosis effect of Penthorum chinense

Interacting binding insights and conformational consequences of the differential activity of cannabidiol with two endocannabinoid-activated G-protein-coupled receptors

Jiawei Runjing Decoction Improves Spermatogenesis of Cryptozoospermia With Varicocele by Regulating the Testicular Microenvironment: Two-Center Prospective Cohort Study

AMTDB: A comprehensive database of autophagic modulators for anti-tumor drug discovery

Pristimerin, a triterpene that inhibits monoacylglycerol lipase activity, prevents the development of paclitaxel-induced allodynia in mice

Melanin-concentrating hormone promotes anxiety and intestinal dysfunction via basolateral amygdala in mice

Editorial: Imaging technology in oncology pharmacological research, volume II

Network pharmacology and molecular docking to elucidate the mechanism of pulsatilla decoction in the treatment of colon cancer

The efficacy and safety of dachaihu decoction in the treatment of type 2 diabetes mellitus: A systematic review and meta-analysis

Traditional chinese medicine in coronary microvascular disease

The Combination of Tamarindus indica and Coenzyme Q10 can be a Potential Therapy Preference to Attenuate Cadmium-Induced Hepatorenal Injury

Editorial: Protein-based nanocarriers for delivery of nutraceutical, diagnostic and therapeutic agents

Global research status and hot trends in stem cells therapy for Intervertebral disc degeneration: A bibliometric and clinical study analysis

Editorial: Zebrafish as a model for pharmacological and toxicological research

A Description of Acute Renal Failure and Nephrolithiasis Associated With Sodium–Glucose Co-Transporter 2 Inhibitor Use: A VigiBase Study

Editorial: Harnessing chemotherapy resistance and development of novel therapeutic strategies for acute leukemia with KMT2A (MLL)-gene rearrangements

Transcranial near-infrared light in treatment of neurodegenerative diseases

miRNAs as Biomarkers and Possible Therapeutic Strategies in Synovial Sarcoma

Adapalene inhibits the growth of triple-negative breast cancer cells by S-phase arrest and potentiates the antitumor efficacy of GDC-0941

Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation

Molecular mechanisms of sacubitril/valsartan in cardiac remodeling

Allyl methyl trisulfide protected against LPS-induced acute lung injury in mice via inhibition of the NF-κB and MAPK pathways

Dihydromyricetin ameliorates osteogenic differentiation of human aortic valve interstitial cells by targeting c-KIT/interleukin-6 signaling pathway

Curcumin and its nano-formulations: Defining triple-negative breast cancer targets through network pharmacology, molecular docking, and experimental verification

Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer

TVGG Dental Implant Identification System

Wenshenyang recipe treats infertility through hormonal regulation and inflammatory responses revealed by transcriptome analysis and network pharmacology

Phenotypic screening of low molecular weight compounds is rich ground for repurposed, on-target drugs

Editorial: Epigenetic mechanisms and post-translational modifications as novel therapeutic targets in cancer

Corrigendum: Effect of Monoacylglycerol Lipase Inhibition on Intestinal Permeability of Rats With Severe Acute Pancreatitis

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A review for discovering bioactive minor saponins and biotransformative metabolites in Panax quinquefolius L.

Content Provider	frontiers
Author	Yang, Zhiyou Deng, Jiahang Liu, Mingxin He, Chuantong Feng, Xinyue Liu, Shucheng Wei, Shuai
Abstract	Panax quinquefolius has attracted extensive attention worldwide because of the prominent biological functions on type 2 diabetes, cancers, central nervous system, and cardiovascular diseases investigated for decades. Active phytochemicals of Panax quinquefolius are ginsenosides, which can be classified as propanaxdiol (PPD)-type, propanaxtriol (PPT)-type, oleanane-type, and ocotillol-type oligo-glycosides depending on the skeleton of aglycone. Recently, advanced analytical and isolated methods including ultra-performance liquid chromatography tandem with mass detector, preparative high-performance liquid chromatography, high speed counter-current chromatography have been used to isolate and identify minor components in Panax quinquefolius, which accelerates the clarification of its material basis. Meanwhile, the poor bioavailability and undetermined bio-metabolism of most saponins has greatly hindered both the development of medicines and the identification of their real active constituents. Thus, it is essential to consider the bio-metabolism of constituents before and after absorption. In this review, we described the structures of minor ginsenosides in Panax quinquefolius, including naturally occurring protype compounds and their in vivo metabolites. The preclinical and clinical pharmacological studies of the ginsenosides in the past few years are also summarized. The review will promote the reacquaint of minor saponins on the growing appreciation of their biological role in Panax quinquefolius.
ISSN	16639812
DOI	10.3389/fphar.2022.972813
Volume Number	13
Journal	Frontiers in Pharmacology
Language	English
Publisher Date	2022-08-01
Access Restriction	Open
Subject Keyword	Minor ginsenosides Structural diversity Pharmacological effects Panax quinquefolius Metabolites
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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