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| Content Provider | frontiers |
|---|---|
| Author | Bijman, Rik Rossi, Linda Janssen, Tomas de Ruiter, Peter van Triest, Baukelien Breedveld, Sebastiaan Sonke, Jan-Jakob Heijmen, Ben |
| Abstract | Background: With the large-scale introduction of volumetric modulated arc therapy (VMAT), selection of optimal beam angles for coplanar static-beam IMRT has increasingly become obsolete. Due to unavailability of VMAT in current MR-linacs, the problem has re-gained importance. An application for automated IMRT treatment planning with integrated, patient-specific computer-optimization of beam angles (BAO) was used to systematically investigate computer-aided generation of beam angle class solutions (CS) for replacement of computationally expensive patient-specific BAO. Rectal cancer was used as a model case. Materials and Methods: 23 patients treated at a Unity MR-linac were included. BAOx plans (x=7-12 beams) were generated for all patients. Analyses of BAO12 plans resulted in CSx class solutions. BAOx plans, CSx plans, and plans with equi-angular setups (EQUIx, x=9-56) were mutually compared. Results: For x>7, plan quality for CSx and BAOx was highly similar, while both were superior to EQUIx. E.g. with CS9, bowel/bladder Dmean reduced by 22% [11%, 38%] compared to EQUI9 (p<0.001)). For equal plan quality, the number of EQUI beams had to be doubled compared to BAO and CS. Conclusions: Computer-generated beam angle CS could replace individualized BAO without loss in plan quality, while reducing planning complexity and calculation times, and resulting in a simpler clinical workflow. CS and BAO largely outperformed equi-angular treatment. With the developed CS, time consuming beam angle re-optimization in daily adaptive MR-linac treatment could be avoided. Further systematic research on computerized development of beam angle class solutions for MR-linac treatment planning is warranted. |
| ISSN | 2234943X |
| DOI | 10.3389/fonc.2021.717681 |
| Volume Number | 11 |
| Journal | Frontiers in Oncology |
| Language | English |
| Publisher Date | 2021-10-01 |
| Access Restriction | Open |
| Subject Keyword | Automated planning Beam angle class solution MR-linac Rectal cancer Beam angle optimization (BAO) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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