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| Content Provider | frontiers |
|---|---|
| Author | Rodriguez, Francisca Seta, Francesca |
| Abstract | energy status of the cell, i.e. NAD+/NADH ratio. In energy excess conditions, such as high-fat diets, SIRT1 activity decreases because of decreased NAD+/NADH ratio, whereas a low-energy status such as fasting, calorie restriction, nutrient deprivation and exercise, could increase SIRT1 activity by increasing the NAD+/NADH ratio. Therefore, SIRT1 is an intracellular energy sensor which detects the concentration of intracellular NAD+, and uses this information to adapt cellular energy output to cellular energy requirements and the mammalian metabolic clock.A further link between SIRT1 and metabolic and oxidative stress has been established in a variety of tissues, in which SIRT1 expression has been shown to boost the cellular anti-oxidant defense, in part via deacetylation and subsequent activation of the anti-oxidant transcription factor Nrf2 or mitochondrial protein p66shc. SIRT1 has also been found to regulate the activity and/or expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha, FOXO family, and p53, which are transcription factors known to regulate the activity of antioxidant enzymes, apoptosis and cell growth. Overall, SIRT1 is a well-established functional link between metabolic activity and genome stability. As such, SIRT1 has been proposed as a viable therapeutic target against diabetes and other aging-associated diseases, in which metabolic and oxidative stresses are the major culprit, including cardiovascular and renal diseases, wh... |
| ISSN | 1664042X |
| DOI | 10.3389/fphys.2021.770386 |
| Volume Number | 12 |
| Journal | Frontiers in Physiology |
| Language | English |
| Publisher Date | 2021-10-22 |
| Access Restriction | Open |
| Subject Keyword | Metabolic and oxidant stress Inflammation Cardiovascular disease Sirtuin-1 (SIRT1) Renal disease |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) |
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