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| Content Provider | frontiers |
|---|---|
| Author | Chen, Lin Zheng, Wei Chen, Gang Liu, Lin-Hua Yao, Jin Chen, Yan |
| Abstract | Background: Aged women appear to be at a higher risk of developing memory impairment than men. Whether menopausal hormone therapy (MHT) could improve memory in postmenopausal women remains unclear. We thus conducted a meta-analysis to investigate the potential effect of MHT on memory, especially verbal memory, in postmenopausal women. Methods: PubMed, Cochrane, Embase, Chinese Biomedical Literature Database and web of ClinicalTrials.gov were systematically searched for randomized controlled trials comparing MHT versus placebo in postmenopausal women. Our primary outcome of interest is memory function. Results: We included 10 studies with 2818 participants in the final analysis. There was no significant differences in immediate recall (weighted mean difference [WMD] 0.34, 95% CI: -0.73, 1.40), delayed recall (WMD 0.99, 95% CI: -0.51, 2.48), short-delay (WMD -0.00, 95% CI: -0.37, 0.37) , and long-delay (WMD -0.19, 95% CI: -0.69, 0.31) recall between WMT and placebo. WMT was associated with a lower digit span forward (mean reduction -0.20, 95% CI: -0.36, -0.03). In women within 5 years of menopause, MHT did not differ in immediate (0.45, 95% CI: -0.75, 1.65) or delayed recall (1.03, 95% CI: -0.93, 3.00), and digit span forward (-0.11, 95% CI: -0.72, 0.50) , when compared to placebo. Conclusion: This meta-analysis suggested that MHT had no effect on verbal memory in postmenopausal women, may impair some domains of short-term memory. Current available evidence does not support MHT for improving memory in women less than 60 years, even in recently menopausal women. |
| ISSN | 16642392 |
| DOI | 10.3389/fendo.2022.894883 |
| Volume Number | 13 |
| Journal | Frontiers in Endocrinology |
| Language | English |
| Publisher Date | 2022-09-06 |
| Access Restriction | Open |
| Subject Keyword | Meta-analysis Menopausal hormone therapy Cognition Menopause Women Systematic review Memory |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism |
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