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| Content Provider | frontiers |
|---|---|
| Author | Kotton, Darrell N. Nilsson, Mikael |
| Abstract | Hypothyroidism has long been treated clinically through hormone replacement because approaches to regenerate damaged, resected, or absent thyroid glandular tissue were unavailable. Emerging discoveries in stem cell biology now have great potential to produce future treatments aimed at reconstitution of thyroid organ function. This Frontiers in Endocrinology "Special Issue" aims to feature new research and review articles that advance the current state of thyroid stem cell research, together with related investigations on normal thyroid development. The scope of this Special Issue includes studies on naturally occurring putative thyroid progenitor or stem cells potentially involved in organogenesis, homeostasis, and regeneration, as well as work focused on engineering thyroid follicular cells in vitro from pluripotent stem cells.The work featured in the current issue rests on a solid foundation of long-standing thyroid developmental biology studies (reviewed in [1]) and more recent research indicating that mouse or human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be triggered to differentiate into hormone-producing thyroid follicular cells in vitro [2; 3]. Advancing this understanding, in this issue Romitti et al. further examine the molecular phenotypes of mouse ESC-derived thyroid follicular cells by applying single cell RNA sequencing in order to examine the global transcriptomes of their engineered in vitro derivatives at single cell reso... |
| ISSN | 16642392 |
| DOI | 10.3389/fendo.2022.848559 |
| Volume Number | 13 |
| Journal | Frontiers in Endocrinology |
| Language | English |
| Publisher Date | 2022-02-08 |
| Access Restriction | Open |
| Subject Keyword | Stem Cells Regeneration Thyroid Progenitors Development |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism |
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